Analog electrical model of the coronary circulation in case of multiple revascularizations

Annals of Biomedical Engineering
Mahmoud MaasraniAgnès Drochon

Abstract

In this work, we propose an analog electrical model of the coronary circulation for patients with obstructive disease undergoing revascularization. In this clinical situation, the collateral circulation to the occluded artery is difficult to ascertain via preoperative measurements and well-developed collaterals might induce long-term restenosis of the revascularized artery due to flow competition mechanisms. The proposed model allows an original biomechanical analysis of per-operative hemodynamic data in order to assess quantitative evaluation of pressures and flows inside the native stenosed arteries, the collateral network and the bypass grafts. Average cardiac cycle values are analysed. In the case of 3-vessel disease and chronic occlusion of the right coronary artery, the quantitative results confirm the protective effects of the collateral flows in the pathological situation, but also show that the revascularization of the occluded right artery is fully justified since the collateral flows remain low, even when the left territory is revascularized. The model thus provides a computational tool to evaluate therapeutic strategies for each patient.

References

Jul 1, 1989·Medical & Biological Engineering & Computing·J Z WangJ Semmlow
Sep 1, 1996·Medical Engineering & Physics·R PietrabissaL Menicanti
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·N SpyrouP G Camici
Jun 19, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·T HirotaniY Nakao
Oct 25, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·H CorbineauA Leguerrier
Nov 22, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·P MassoudyH Jakob
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Maria SiebesJos A E Spaan
May 21, 2003·Circulation·Jeroen KoerselmanDiederick E Grobbee
Sep 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Christoph SchmitzArmin Welz
Nov 7, 2003·The Annals of Thoracic Surgery·Wim StookerLéon Eijsman
Sep 24, 2004·Physiological Measurement·Maartje C F GevenFrans N van de Vosse
Oct 20, 2004·Coronary Artery Disease·Mark J Mason
Nov 25, 2004·The Annals of Thoracic Surgery·Henrik K KjaergardThomas A Schmidt
Mar 5, 2005·Biomedical Engineering Online·Meena SankaranarayananYong Seng Tan
May 1, 1969·Journal of Biomechanics·N WesterhofA Noordergraaf
Jan 4, 2006·Annals of Biomedical Engineering·Fumihiko KajiyaStéphane Carlier
Nov 23, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jean-Philippe VerhoyeHervé Corbineau
Dec 19, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·David GlineurClaude Hanet
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Jean-Philippe VerhoyeHervé Corbineau
Aug 3, 2007·Medical & Biological Engineering & Computing·Fernando CachoGerhard A Holzapfel
Jun 1, 2004·Mathematical Biosciences and Engineering : MBE·Mette S Olufsen, Ali Nadim

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Citations

Sep 29, 2011·Cardiology in the Young·Mehmet KorurekAlparslan Şahin
May 16, 2012·Medical Engineering & Physics·Mahmoud MaasraniJean-Philippe Verhoye
Mar 25, 2014·IEEE Transactions on Bio-medical Engineering·David OjedaAlfredo I Hernández
Nov 24, 2018·Scientific Reports·P J BlancoR A Feijóo

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