Analogous synaptic plasticity profiles emerge from disparate channel combinations

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Arun Anirudhan, Rishikesh Narayanan

Abstract

An open question within the Bienenstock-Cooper-Munro theory for synaptic modification concerns the specific mechanism that is responsible for regulating the sliding modification threshold (SMT). In this conductance-based modeling study on hippocampal pyramidal neurons, we quantitatively assessed the impact of seven ion channels (R- and T-type calcium, fast sodium, delayed rectifier, A-type, and small-conductance calcium-activated (SK) potassium and HCN) and two receptors (AMPAR and NMDAR) on a calcium-dependent Bienenstock-Cooper-Munro-like plasticity rule. Our analysis with R- and T-type calcium channels revealed that differences in their activation-inactivation profiles resulted in differential impacts on how they altered the SMT. Further, we found that the impact of SK channels on the SMT critically depended on the voltage dependence and kinetics of the calcium sources with which they interacted. Next, we considered interactions among all the seven channels and the two receptors through global sensitivity analysis on 11 model parameters. We constructed 20,000 models through uniform randomization of these parameters and found 360 valid models based on experimental constraints on their plasticity profiles. Analyzing these 360 ...Continue Reading

Citations

May 29, 2015·The Journal of Physiology·Anindita Das, Rishikesh Narayanan
Apr 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Manisha Sinha, Rishikesh Narayanan
Dec 2, 2015·Journal of Computational Neuroscience·Warren D AndersonRajanikanth Vadigepalli
Apr 21, 2016·Scientific Reports·Rahul Kumar RathourRishikesh Narayanan
Dec 28, 2016·The Journal of Physiology·Chinmayee L Mukunda, Rishikesh Narayanan
Mar 30, 2017·Frontiers in Cellular Neuroscience·Anindita DasRishikesh Narayanan
Jun 13, 2018·The Journal of Physiology·Reshma Basak, Rishikesh Narayanan
Nov 2, 2018·PLoS Computational Biology·Reshma Basak, Rishikesh Narayanan
Jul 14, 2019·Hippocampus·Rahul K Rathour, Rishikesh Narayanan
Feb 22, 2017·Journal of Mathematical Neuroscience·Lawrence C UdeigweG Bard Ermentrout
Jan 17, 2020·Scientific Reports·Abha Jain, Rishikesh Narayanan
May 18, 2021·Current Research in Neurobiology·Poonam Mishra, Rishikesh Narayanan
Aug 17, 2021·Neural Networks : the Official Journal of the International Neural Network Society·Ankit Roy, Rishikesh Narayanan
Aug 21, 2021·Current Opinion in Neurobiology·Poonam Mishra, Rishikesh Narayanan
Nov 19, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mohammad Amin Kamaleddin

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