Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3).

Journal of Human Genetics
Vibha BhatnagarSanjay K Nigam

Abstract

Kidney excretion of numerous organic anionic drugs and endogenous metabolites is carried out by a family of multispecific organic anion transporters (OATs). Two closely related transporters, SLC22A6, initially identified by us as NKT and also known as OAT1, and SLC22A8, also known as OAT3 and ROCT, are thought to mediate the initial steps in the transport of organic anionic drugs between the blood and proximal tubule cells of the kidney. Coding region polymorphisms in these genes are infrequent and pairing of these genes in the genome suggests they may be coordinately regulated. Hence, 5' regulatory regions of these genes may be important factors in human variation in organic anionic drug handling. We have analyzed novel single nucleotide polymorphisms in the evolutionarily conserved 5' regulatory regions of the SLC22A6 and SLC22A8 genes (phylogenetic footprints) in an ethnically diverse sample of 96 individuals (192 haploid genomes). Only one polymorphism was found in the SLC22A6 5' regulatory region. In contrast, seven polymorphisms were found in the SLC22A8 5' regulatory region, two of which were common to all ethnic groups studied. Computational analysis permitted phase and haplotype reconstruction. Proximity of these non-c...Continue Reading

References

Dec 31, 2002·Biochemical and Biophysical Research Communications·Satish A EralySanjay K Nigam
Feb 24, 2004·Molecular Pharmacology·Satish A EralySanjay K Nigam
Apr 6, 2004·Molecular Phylogenetics and Evolution·Sonja J ProhaskaPeter F Stadler
Mar 18, 2005·Physiology·Matthias A HedigerHitoshi Endou
Apr 23, 2005·Toxicology and Applied Pharmacology·Douglas H Sweet
May 3, 2005·Pharmacogenetics and Genomics·Tomoe FujitaKathleen M Giacomini
May 26, 2005·The Journal of Pharmacology and Experimental Therapeutics·Kelly BleasbyJohn B Pritchard
May 28, 2005·Current Rheumatology Reports·Naohiko AnzaiHitoshi Endou
Dec 16, 2005·The Journal of Biological Chemistry·Satish A EralySanjay K Nigam

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Citations

Apr 17, 2008·Journal of Human Genetics·Ken OgasawaraKen-Ichi Inui
Jan 1, 2011·Pharmacogenomics and Personalized Medicine·Jing Li, Martin H Bluth
May 8, 2013·Journal of Pharmaceutical Sciences·Sook Wah YeeKathleen M Giacomini
Jun 6, 2008·Journal of Clinical Pharmacology·J Andrew WilliamsSteven A Wrighton
Dec 6, 2014·Nature Reviews. Drug Discovery·Sanjay K Nigam
Jul 27, 2007·Nature Clinical Practice. Nephrology·Sanjay K NigamVibha Bhatnagar
Jul 14, 2009·Current Opinion in Nephrology and Hypertension·Chris Cheeseman
Oct 23, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Sanjay K NigamVibha Bhatnagar
Jan 25, 2008·American Journal of Physiology. Renal Physiology·Volker VallonSanjay K Nigam
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C SrimaroengJ B Pritchard
Mar 30, 2012·Pharmacological Reviews·Arian Emami RiedmaierMatthias Schwab
Mar 9, 2007·American Journal of Physiology. Renal Physiology·Ken OgasawaraKen-ichi Inui
Dec 30, 2014·Physiological Reviews·Sanjay K NigamWei Wu
Mar 20, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Jeremiah D MomperSanjay K Nigam
Feb 8, 2019·Nature Reviews. Nephrology·Sanjay K Nigam, Kevin T Bush
Jun 7, 2012·Chemical Research in Toxicology·Rudolfs K Zalups, Christy C Bridges

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