Analyses of dose-response in radiotherapy for patients with mature T/NK-cell lymphomas according to the WHO classification

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Koh-ichi SakataMasato Hareyama

Abstract

This study was conducted to analyze the influence of radiotherapy doses and chemotherapy doses and clinical parameters on in-field disease control in order to assess the optimal radiation doses for treatment of mature T/NK-cell lymphomas according to the newly proposed WHO classification. Subjects consisted of 62 patients with mature T/NK-cell lymphomas treated with radiotherapy at four Japanese institutions between 1983 and 2002. We reevaluated all histopathological specimens of non-Hodgkin's lymphomas (NHL), using the WHO classification. Radiation therapy was usually delivered to the involved field. The majority of patients also received adriamycin-based chemotherapy such as CHOP, modified CHOP, or more intensive chemotherapy. There were no significant differences in radiosensitivity among subtypes of mature T/NK-cell lymphomas, at least between extranodal NK/T-cell lymphomas, nasal type and peripheral T-cell lymphomas, unspecified. There was a radiation dose-response in non-bulky mature T/NK-cell lymphomas, indicating that radiation doses of more than 52 Gy may be required to obtain in-field control. However, it was difficult to obtain local control of bulky T-cell lymphomas, even with high doses of irradiation. Mature T/NK-...Continue Reading

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Citations

Apr 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P CorradiniS Tura
Nov 19, 2010·International Journal of Hematology·Seok Jin Kim, Won Seog Kim
Apr 29, 2010·Current Hematologic Malignancy Reports·John P Greer, Claudio A Mosse
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Oct 16, 2015·International Journal of Radiation Oncology, Biology, Physics·Dongryul OhYoung Hyeh Ko
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Jun 18, 2017·Expert Review of Anticancer Therapy·Vadim S Pokrovsky, Denis Vinnikov
Apr 1, 2018·Blood·Motoko YamaguchiMasahiko Oguchi

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