Analyses of molecular and histopathologic features and expression of PRAME by immunohistochemistry in mucosal melanomas

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Aimi ToyamaFaqian Li

Abstract

Mucosal melanomas are rare, and less is known about the biomarkers of this subtype in comparison to cutaneous or uveal melanomas. Preferentially expressed antigen in melanoma (PRAME) has been studied as a tool for prognostication of uveal melanomas, and immunotherapy against PRAME-expressing tumor cells has already shown promise. Our goal was to retrospectively analyze 29 cases of mucosal melanomas at our institution to determine if any molecular and histopathologic prognosticators could be identified, as well as to study PRAME expression and its association with prognosis. We found that the majority of mucosal melanomas expressed PRAME and a high PRAME expression score predicted a poor prognosis. There was no association between prognosis and the histomorphologic features analyzed, such as presence of spindle cell or epithelioid predominance. BRAF mutations were absent in 16 of 16 cases tested. Pathogenic NRAS mutations were detected in 3 of 11 cases tested and were associated with shorter overall survival compared to those without NRAS alterations, but the presence of NRAS mutations did not correlate with PRAME expression. In conclusion, an increase in PRAME expression and the presence of a pathogenic NRAS were both associate...Continue Reading

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Citations

Jan 13, 2021·Journal of Cutaneous Pathology·Mary E LohmanJeffrey P North
Mar 5, 2021·Journal of Cutaneous Pathology·Ahmed K AlomariRachel P Kowal
Sep 21, 2020·Archives of Medical Research·Carlos Torres-CabalaWen-Jen Hwu
Apr 24, 2021·International Journal of Surgical Pathology·Cecilia LezcanoAchim A Jungbluth
May 3, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Ping YangQuansheng Zhou
May 24, 2021·Surgical Pathology Clinics·Cecilia LezcanoKlaus J Busam
May 24, 2021·Surgical Pathology Clinics·Robert V RawsonRichard A Scolyer
Aug 29, 2021·Oral Oncology·Daniel HovanderAta S Moshiri
Jul 17, 2021·Histopathology·Daja ŠekoranjaJože Pižem
Jun 25, 2021·Journal of Cutaneous Pathology·Pavandeep GillCarlos A Torres-Cabala

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