Analyses of Potential Driver and Passenger Bacteria in Human Colorectal Cancer

Cancer Management and Research
Yijia WangXuehua Wan

Abstract

Besides genetic and epigenetic alterations that lead to carcinogenesis and development of colorectal cancer (CRC), intestinal microbiomes are recently recognized to play a critical role in CRC progression. The abundant species associated with human CRC have been proposed for their roles in promoting tumorigenesis. However, a recent "driver-passenger" model suggests that these CRC-associated species with high relative abundances may be passenger bacteria that take advantage of the tumor environment instead of initiating CRC, whereas the driver species that initiate CRC have been replaced by passenger bacteria due to the alteration of the intestinal niche. Here, to reveal potential driver and passenger bacteria during CRC progression, we compare the gut mucosal microbiomes of 75 triplet-paired CRC samples collected from on-tumor site, adjacent-tumor site, and off-tumor site, and 26 healthy controls. Our analyses revealed potential driver bacteria in four genera and two families, and potential passenger bacteria in 14 genera or families. Bacillus, Bradyrhizobium, Methylobacterium, Streptomyces, Intrasporangiaceae and Sinobacteraceae were predicted to be potential driver bacteria. Moreover, 14 potential passenger bacteria were iden...Continue Reading

References

Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Jun 3, 2011·The Journal of Clinical Investigation·Herbert Tilg, Arthur Kaser
Oct 20, 2011·Genome Research·Mauro CastellarinRobert A Holt
Oct 20, 2011·Genome Research·Aleksandar D KosticMatthew Meyerson
Feb 16, 2012·BMC Bioinformatics·Andre P MasellaJosh D Neufeld
Apr 14, 2012·The Journal of Nutrition, Health & Aging·G MalaguarneraM Salmeri
Jun 26, 2012·Nature Reviews. Microbiology·Harold TjalsmaBas E Dutilh
Nov 28, 2012·BMC Surgery·Mario UccelloAntonio Biondi
Dec 5, 2013·Carcinogenesis·Scott J Bultman
Jan 24, 2014·Microbiome·René L WarrenRobert A Holt
May 28, 2014·FEMS Microbiology Reviews·Mirjana Rajilić-Stojanović, Willem M de Vos
Feb 24, 2015·Frontiers in Microbiology·Zhiguang GaoHuanlong Qin
Oct 31, 2015·Nature Communications·Geicho NakatsuJoseph J Y Sung
Sep 28, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Vanessa L HaleNicholas Chia
Jan 18, 2017·Cancer Prevention Research·Seesandra V RajagopalaKaren E Nelson
Apr 5, 2017·Annual Review of Genomics and Human Genetics·Rob KnightMitchell L Sogin
Apr 17, 2018·Cancer Cell·Herbert TilgAlexander R Moschen
Aug 10, 2019·Cell·Erick RiquelmeFlorencia McAllister
Sep 9, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jing JinWeimin Li
Mar 3, 2020·Frontiers in Oncology·Zahra Eslami-SRezvan Esmaeili

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Citations

Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Ting DongZhengwei Huang

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Datasets Mentioned

BETA
PRJNA606879

Software Mentioned

Cytoscape
QIIME
FastQC
R package Hmisc

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