Analyses of prealbumin mRNAs in individuals with familial amyloidotic polyneuropathy

Journal of Biochemistry
S MitaS Araki

Abstract

The distribution of prealbumin mRNA in various tissues of a control subject and an individual with familial amyloidotic polyneuropathy (FAP) was investigated using a cloned human prealbumin cDNA as a probe. Prealbumin mRNAs were detected in the total RNAs from liver and choroid plexus of brain, but not in those from brain, heart, kidney, and thyroid gland. The level of prealbumin mRNA in the choroid plexus was about 100-fold higher than that in the liver. We detected no differences in the sizes of prealbumin mRNAs in the liver and choroid plexus of the control subject, or in those of the individual with FAP, and found that the prealbumin mRNAs in these tissues had been transcribed from a common transcription initiation site. The levels of prealbumin mRNAs in the livers of four control subjects and those of six individuals with FAP were much the same. Because all the individuals with FAP so far examined were heterozygous for the prealbumin gene, carrying one normal and one mutant gene, the levels of the normal and mutant prealbumin mRNAs in the liver and the brain tissue containing choroid plexus were separately estimated and were found to be approximately equal.

Citations

Apr 23, 2014·Journal of Clinical Pharmacy and Therapeutics·Y Sekijima
Dec 30, 2014·British Journal of Clinical Pharmacology·Karen J KlamerusSteve Riley
Apr 28, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Luísa Lobato, Ana Rocha
Oct 1, 1995·Neuropathology and Applied Neurobiology·S AlbrechtT Pietsch
Jan 1, 1995·Pathology International·T MurakamiM Ando
Dec 12, 1997·European Journal of Biochemistry·I Longo AlvesM J Saraiva
Dec 10, 2008·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Joel BuxbaumLawreen H Connors
Oct 9, 2013·Journal of Cardiovascular Translational Research·Giampaolo MerliniDonna R Grogan
May 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A R AldredG Schreiber
Feb 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G Schreiber, S J Richardson
Jun 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·G SchreiberS C Nicol
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·P J HarmsG Schreiber
Jan 1, 1990·Critical Reviews in Oncology/hematology·R A Kyle, M A Gertz
Apr 15, 2008·Neuroscience Letters·Tatsufumi MurakamiYoshihide Sunada

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