PMID: 9180907Aug 1, 1997Paper

Analyses of prognostic factors in a retrospective review of 92 children with ependymoma: Italian Pediatric Neuro-oncology Group

Medical and Pediatric Oncology
G PerilongoE Madon

Abstract

The principal aim of this report is to present the results of multivariate analyses conducted to identify clinical prognostic factors in 92 children aged < 16 years with ependymoma (EPD) retrospectively collected in seven Italian centres. They were treated over a 16-year period (1977-1993). Treatment modalities varied. Surgery and radiotherapy (RT) was the "gold standard" management method for the majority of these children. Only in the late 1980s did some of them receive chemotherapy (CT), mainly with vincristine, lomustine (CCNU) and prednisone. The median follow-up of the entire study population is 36 months (average 43 months; range 12 to 214 months). The 10-year overall (OS) and the progression-free survival (PFS) of the study population were 55.5% (CI 41.4-69.4%) and 34.7% (CI 21.4-47.8%), respectively. Age (< 5 years; > 5 years), sex, site (infratentorial vs. supratentorial), histology (anaplastic/malignant vs. non-anaplastic/non-malignant), type of resection (complete vs. incomplete); use and fields of RT, and of CT employed were entered in a multivariate regression model to test their impact on OS and PFS. On univariate analysis, radical surgery, the use of RT and age more than 5 years at the time of diagnosis achieved...Continue Reading

References

Jul 1, 1992·Journal of Neuro-oncology·J K ChiuR Shallenberger
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L J VanuytselM Brada
Aug 1, 1991·International Journal of Radiation Oncology, Biology, Physics·L Vanuytsel, M Brada
Mar 1, 1990·Journal of Neurosurgery·G B NazarE B Hendrick
Oct 1, 1987·International Journal of Radiation Oncology, Biology, Physics·E G ShawJ D Earle
Nov 1, 1986·International Journal of Radiation Oncology, Biology, Physics·K E WallnerR L Davis
Aug 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C CarrieM Brunat-Mentigny
Jan 15, 1994·International Journal of Radiation Oncology, Biology, Physics·P RousseauA Rey
Feb 1, 1993·Journal of Neuro-oncology·J J KovalicK A Roth
Oct 1, 1949·Journal of Neuropathology and Experimental Neurology·N RINGERTZ, A REYMOND

❮ Previous
Next ❯

Citations

Aug 15, 2008·Neuro-oncology·Lee RidleyUNKNOWN Children's Cancer and Leukaemia Group Biological Studies Committee
Feb 13, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Karen D Wright, Amar Gajjar
Mar 17, 2009·Future Oncology·Maura MassiminoFelice Giangaspero
Aug 3, 2010·Journal of Neurosurgery. Pediatrics·Martin BeneschStefan Rutkowski
Nov 3, 2010·Journal of Neurosurgery. Pediatrics·Hideyuki KanoL Dade Lunsford
Sep 3, 2011·Journal of Neurosurgery. Pediatrics·Maura MassiminoLorenza Gandola
Apr 2, 2013·Journal of Neurosurgery. Pediatrics·Tene A CageKurtis I Auguste
Oct 3, 2000·Journal of Neurosurgery·D Figarella-BrangerJ F Pellissier
Oct 3, 2000·Journal of Neurosurgery·R J Packer
Oct 31, 2002·Journal of Neurosurgery·Marie-Lise C van Veelen-VincentDominique Renier
May 6, 2005·Journal of Neurosurgery·Leland RogersBurton Speiser
May 29, 2015·Pediatric Blood & Cancer·Jonathan E FrandsenMatthew M Poppe
Jul 31, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·K VaidyaJanet R Williams
Feb 14, 2012·Current Problems in Cancer·Michael D Chan, Kevin P McMullen
Jan 25, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M HoujamiA Benider
Dec 6, 2002·The American Journal of Pathology·Sara DyerRichard Grundy
Mar 10, 2016·Neurology India·Rony BensonGoura K Rath
Mar 11, 2009·The Lancet Oncology·Thomas E MerchantRobert A Sanford
Mar 8, 2008·International Journal of Radiation Oncology, Biology, Physics·Shannon M MacDonaldTorunn Yock
Feb 9, 2008·International Journal of Radiation Oncology, Biology, Physics·Thomas M SchroederArnold C Paulino
Jul 24, 2007·The Lancet Oncology·Richard G GrundyUNKNOWN Children's Cancer and Leukaemia Group (formerly UKCCSG) Brain Tumour Committee
May 8, 2007·Critical Reviews in Oncology/hematology·Michele ReniCharles Vecht
Jul 5, 2007·Pediatric Blood & Cancer·Stergios ZacharoulisRichard Sposto
Jul 25, 2008·Journal of Cellular Physiology·Matthias KarajannisElizabeth W Newcomb
Mar 4, 2011·Pediatric Blood & Cancer·Rajkumar VenkatramaniJonathan L Finlay
Mar 13, 2014·Pediatric Blood & Cancer·Reuben AntonyJonathan L Finlay
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·David B MansurJoseph R Simpson
Mar 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Maura MassiminoUNKNOWN AIEOP Pediatric Neuro-Oncology Group
Jul 26, 2006·International Journal of Radiation Oncology, Biology, Physics·Maura MassiminoUNKNOWN AIEOP Neuro-Oncology Group
Jun 7, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tryggve LundarPetter Brandal
Nov 14, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tamir AilonJuliette Hukin
Nov 23, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Piergiorgio ModenaGabriella Sozzi
Feb 5, 2009·Neurosurgery·Hideyuki KanoL Dade Lunsford
Apr 24, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·G TamburriniC Di Rocco
Apr 10, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mark D Krieger, J Gordon McComb
Oct 21, 2009·Journal of Child Neurology·Mark M Souweidane
Oct 21, 2009·Journal of Child Neurology·Stergios Zacharoulis, Lucas Moreno
Apr 20, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·R AhmadiH H Steiner
Mar 8, 2018·Journal of Neuro-oncology·Brian DeSuzanne L Wolden
Sep 1, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Elvis Terci ValeraLuiz Gonzaga Tone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.