Analyses of reported family history of glaucoma: a preliminary investigation. The Barbados Eye Study Group

Ophthalmic Epidemiology
B NemesureN Mendell

Abstract

This study investigated the self-reported family history of open-angle glaucoma (OAG) among 4,314 black participants in the Barbados Eye Study (BES), which was based on a random sample of Barbados-born citizens between 40 and 84 years of age. Data collection included Humphrey perimetry, fundus photography, various ophthalmic and other measurements and a comprehensive interview, including family history. Results showed that participants with OAG and previous OAG treatment reported more family history; maternal history was reported twice as often as paternal history. In persons without previous OAG treatment, those with newly diagnosed OAG reported more sibling history (Odds Ratio = 4.5). The Statistical Analysis for Genetic Epidemiology (S.A.G.E.) system was used to test the transmission models for OAG in a subset of 1,048 families (5,806 individuals) with the most complete self-reported family information. The S.A.G.E. results are consistent with the existence of a major dominant allele for OAG. These results should be viewed as promising, but preliminary, since they are based on self-reported data. More definitive information is currently being collected by the Barbados Family Study of Open-angle Glaucoma.

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Citations

Jul 13, 2000·Ophthalmology·R L NguyenE I Traboulsi
May 31, 2001·Ophthalmology·M C LeskeA Hennis
Jan 21, 2014·International Ophthalmology·Bola J AdekoyaAbdulkabir A Ayanniyi
Dec 25, 2009·Ophthalmology·Gisèle LiPaul Harasymowycz
Jul 17, 2007·Ophthalmology·M Cristina LeskeUNKNOWN BESs Study Group
Nov 14, 2007·Clinical & Experimental Ophthalmology·Robert J CassonThan Aung
Mar 13, 2003·Acta Ophthalmologica Scandinavica·A TuulonenM-L Vuori
Mar 10, 2015·Ophthalmology·Yih-Chung ThamUNKNOWN International Glaucoma Genetics Consortium
Sep 20, 2001·American Journal of Medical Genetics·B NemesureUNKNOWN Barbados Family Study Group
Jan 5, 2008·Clinical & Experimental Ophthalmology·Catherine M GreenDavid A Mackey
Dec 17, 2011·Clinical & Experimental Ophthalmology·Emmanuelle SouzeauJamie E Craig
Sep 16, 2020·Investigative Ophthalmology & Visual Science·Nigus G AsefaHarold Snieder
Jan 17, 2003·Ophthalmic Epidemiology·Paul MitchellJie Jin Wang
Jan 18, 2019·Experimental Eye Research·Harini V GudisevaJoan M O'Brien
Sep 1, 2014·Journal of Current Glaucoma Practice·Sharmila RajendrababuS R Krishnadas

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