Analysis and characterization of the complete genome of tupaia (tree shrew) herpesvirus

Journal of Virology
Udo Bahr, G Darai

Abstract

The tupaia herpesvirus (THV) was isolated from spontaneously degenerating tissue cultures of malignant lymphoma, lung, and spleen cell cultures of tree shrews (Tupaia spp.). The determination of the complete nucleotide sequence of the THV strain 2 genome resulted in a 195,857-bp-long, linear DNA molecule with a G+C content of 66.5%. The terminal regions of the THV genome and the loci of conserved viral genes were found to be G+C richer. Furthermore, no large repetitive DNA sequences could be identified. This is in agreement with the previous classification of THV as the prototype species of herpesvirus genome group F. The search for potential coding regions resulted in the identification of 158 open reading frames (ORFs) regularly distributed on both DNA strands. Seventy-six out of the 158 ORFs code for proteins that are significantly homologous to known herpesvirus proteins. The highest homologies found were to primate and rodent cytomegaloviruses. Biological properties, protein homologies, the arrangement of conserved viral genes, and phylogenetic analysis revealed that THV is a member of the subfamily Betaherpesvirinae. The evolutionary lineages of THV and the cytomegaloviruses seem to have branched off from a common ancesto...Continue Reading

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F Liu, B Roizman
Mar 12, 1992·Nature·M J Novacek
Mar 1, 1991·Journal of Virology·M MesserleU H Koszinowski
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jan 1, 1989·Annual Review of Microbiology·D J McGeoch
Jul 1, 1988·The Journal of General Virology·D J McGeochP Taylor
Jul 1, 1985·Journal of Virology·H G KochG Darai
Jan 1, 1981·Journal of Medical Primatology·W HofmannG Darai
Jan 1, 1984·Journal of Virology·R M StenbergM F Stinski
Mar 31, 1995·Journal of Molecular Biology·D J McGeochE A Telford
Mar 1, 1995·Journal of Virology·J A Smith, G S Pari
Mar 1, 1994·Journal of Virology·S KarlinG A Schachtel
Apr 22, 1994·Journal of Molecular Biology·D J McGeoch, S Cook
Dec 1, 1996·Journal of Virology·W D RawlinsonB G Barrell

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Citations

Aug 21, 2003·Journal of Biomedical Science·John Nicholas
May 26, 2012·Medical Microbiology and Immunology·Lin WangChunfu Zheng
Dec 18, 2010·Bulletin of Experimental Biology and Medicine·A A AgumavaB A Lapin
May 19, 2010·Virus Genes·Nurith J JakobHans R Gelderblom
Nov 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rebecca L Vega ThurberForest L Rohwer
Oct 14, 2011·Journal of Virology·Angie K MarshKelly S MacDonald
May 28, 2003·Journal of Virology·Scott G HansenScott W Wong
Mar 14, 2003·Journal of Virology·Eva SchöndorfGholamreza Darai
Nov 19, 2008·Virology Journal·Mark R SchleissMichael A McVoy
Dec 9, 2009·Virus Research·Sourav Roychoudhury, Debaprasad Mukherjee
May 25, 2002·The Journal of General Virology·Richard AdairDerrick J Dargan
Mar 30, 2010·Veterinary Microbiology·Andrew J Davison
Jan 21, 2003·The Journal of General Virology·Andrew J DavisonGary S Hayward
Feb 27, 2003·The Journal of General Virology·Andrew J DavisonGavin W G Wilkinson
Sep 6, 2018·Molecular Neurobiology·Catherine H Schein

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