Analysis and identification of novel biomarkers involved in neuroblastoma via integrated bioinformatics.

Investigational New Drugs
Bo ChenZhijie Li

Abstract

Neuroblastoma (NB) is the most common extracranial solid tumor in children. Under various treatments, some patients still have a poor prognosis. Hence, it is necessary to find new valid targets for NB therapy. In this study, a comprehensive bioinformatic analysis was used to identify differentially expressed genes (DEGs) between NB and control cells, and to select hub genes associated with NB. GSE66586 and GSE78061 datasets were downloaded from the Gene Expression Omnibus (GEO) database and DEGs were selected. Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were applied to the selected DEGs. The STRING database and Cytoscape software were used to construct protein-protein interaction (PPI) networks and perform modular analysis of the DEGs. The R2 database was used for prognostic analysis. We identified a total of 238 DEGs from two microarray databases. GO enrichment analysis shows that these DEGs are mainly concentrated in the regulation of cell growth, cell migration, cell fate determination, and cell maturation. KEGG pathway analysis showed that these DEGs are mainly involved in focal adhesion, the TNF signaling pathway, cancer-related pathways, and signaling pathways regulating stem cell ...Continue Reading

References

Dec 10, 1998·Nucleic Acids Research·H OgataM Kanehisa
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Mar 4, 2003·Nature Reviews. Cancer·Garrett M Brodeur
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Nov 14, 2006·Nucleic Acids Research·Tanya BarrettRon Edgar
Jun 26, 2007·Lancet·John M MarisSusan L Cohn
Mar 20, 2010·Nucleic Acids Research·Xiao-Qin XiaYipeng Wang
May 13, 2010·Journal of Experimental & Clinical Cancer Research : CR·Petr ChlapekRenata Veselska
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Navin R PintoSusan L Cohn
Oct 27, 2015·Acta Biomaterialia·Robert CoyleYing Mei
Mar 24, 2016·Methods in Molecular Biology·Emily Clough, Tanya Barrett
Oct 13, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lori S HartJohn M Maris
Mar 8, 2018·Journal of the National Cancer Institute·Pauline DepuydtKatleen De Preter
Aug 24, 2018·Bioinformatics·Daniel Toro-DomínguezPedro Carmona-Sáez
Oct 26, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Min LiHong-Bo Wang
Nov 20, 2018·Journal of Proteome Research·Nadezhda T DonchevaLars J Jensen
Mar 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhen-Mei SongShi-Yu Du
May 1, 2019·BMC Medical Genetics·Daniela Palheiro Mendes-de-AlmeidaMaria S Pombo-de-Oliveira
Jan 5, 2020·Nature Communications·Elin AlmstedtSven Nelander
Jan 30, 2020·International Journal of Molecular Sciences·Antonio Villalobo, Martin W Berchtold
Feb 19, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F BertholdT Simon
Mar 14, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeong A Park, Nai-Kong V Cheung
Apr 8, 2020·Cells·Maximilian ScheerVinayaga Srinivasan Gnanapragassam

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Mar 6, 2021·Investigational New Drugs·Feng-Ling ShaoShan Wang

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