PMID: 16532936Mar 15, 2006Paper

Analysis and minimization of overtraining effect in rule-based classifiers for computer-aided diagnosis

Medical Physics
Qiang Li, Kunio Doi

Abstract

Computer-aided diagnostic (CAD) schemes have been developed to assist radiologists detect various lesions in medical images. In CAD schemes, classifiers play a key role in achieving a high lesion detection rate and a low false-positive rate. Although many popular classifiers such as linear discriminant analysis and artificial neural networks have been employed in CAD schemes for reduction of false positives, a rule-based classifier has probably been the simplest and most frequently used one since the early days of development of various CAD schemes. However, with existing rule-based classifiers, there are major disadvantages that significantly reduce their practicality and credibility. The disadvantages include manual design, poor reproducibility, poor evaluation methods such as resubstitution, and a large overtraining effect. An automated rule-based classifier with a minimized overtraining effect can overcome or significantly reduce the extent of the above-mentioned disadvantages. In this study, we developed an "optimal" method for the selection of cutoff thresholds and a fully automated rule-based classifier. Experimental results performed with Monte Carlo simulation and a real lung nodule CT data set demonstrated that the au...Continue Reading

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Citations

Apr 25, 2008·Nihon Hoshasen Gijutsu Gakkai zasshi·Megumi YamamotoTakayuki Ishida
Mar 24, 2012·The Journal of Surgical Research·Bolanle AsiyanbolaRalph Etienne-Cummings
Mar 30, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ou BaiMary Kay Floeter
Sep 29, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Harsha BattapadyOu Bai
Dec 18, 2007·Computer Methods and Programs in Biomedicine·Xingwei WangHong Liu
Mar 21, 2007·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Qiang Li
Mar 21, 2007·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Qiang Li
Jan 15, 2014·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Peng CaoOsmar Zaiane
Sep 22, 2018·Journal of Thoracic Imaging·Jiali CaiMatthew D Cham
Mar 4, 2017·Computer Methods and Programs in Biomedicine·Peng CaoOsmar Zaiane

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