Analysis and prediction of defects in UV photo-initiated polymer microarrays

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Andrew L HookMorgan R Alexander

Abstract

Polymer microarrays are a key enabling technology for the discovery of novel materials. This technology can be further enhanced by expanding the combinatorial space represented on an array. However, not all materials are compatible with the microarray format and materials must be screened to assess their suitability with the microarray manufacturing methodology prior to their inclusion in a materials discovery investigation. In this study a library of materials expressed on the microarray format are assessed by light microscopy, atomic force microscopy and time-of-flight secondary ion mass spectrometry to identify compositions with defects that cause a polymer spot to exhibit surface properties significantly different from a smooth, round, chemically homogeneous 'normal' spot. It was demonstrated that the presence of these defects could be predicted in 85% of cases using a partial least square regression model based upon molecular descriptors of the monomer components of the polymeric materials. This may allow for potentially defective materials to be identified prior to their formation. Analysis of the PLS regression model highlighted some chemical properties that influenced the formation of defects, and in particular suggeste...Continue Reading

References

Sep 18, 1998·Journal of Biomedical Materials Research·S BrocchiniJ Kohn
Mar 26, 2003·Journal of Chemical Information and Computer Sciences·Christoph SteinbeckEgon Willighagen
Jun 15, 2004·Nature Biotechnology·Daniel G AndersonRobert Langer
Mar 15, 2005·Biomaterials·Daniel G AndersonRobert Langer
Mar 23, 2005·Nature Methods·Christopher J FlaimSangeeta N Bhatia
May 17, 2006·Chemical Communications : Chem Comm·Guilhem TourniaireMark Bradley
Jun 27, 2006·Current Pharmaceutical Design·Christoph SteinbeckEgon L Willighagen
May 17, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Michael TaylorMorgan R Alexander
Jun 23, 1995·Science·X D XiangP G Schultz
Dec 31, 2008·Angewandte Chemie·Ferdous KhanMark Bradley
Jan 23, 2009·Biomacromolecules·Andrew L HookNicolas H Voelcker
Apr 1, 2009·Biomacromolecules·Mahaveer D KurkuriNicolas H Voelcker
May 5, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew L HookNicolas H Voelcker
Jun 18, 2009·Combinatorial Chemistry & High Throughput Screening·Guilhem TourniaireMark Bradley
Oct 10, 2009·Biomaterials·Andrew L HookMorgan R Alexander
Sep 3, 2010·Biofabrication·Andrew L HookNicolas H Voelcker
Aug 11, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nikolaos ScoutarisClive J Roberts
Feb 9, 2012·Journal of Visualized Experiments : JoVE·Andrew L HookMorgan R Alexander
Aug 14, 2012·Nature Biotechnology·Andrew L HookMorgan R Alexander
Mar 2, 2013·Surface and Interface Analysis : SIA·David J ScurrMorgan R Alexander
Oct 5, 2013·Journal of Materials Chemistry·V Chandana EpaDavid A Winkler
Feb 1, 2009·Surface and Interface Analysis : SIA·Michael TaylorMorgan R Alexander

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Citations

Jul 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohammed S AlgahtaniMartyn C Davies
Dec 11, 2014·Advanced Healthcare Materials·Olutoba SanniAndrew L Hook
Feb 25, 2015·Biointerphases·Andrew L HookDavid J Scurr
May 3, 2016·Surface and Interface Analysis : SIA·Andrew L Hook, David J Scurr
Oct 24, 2018·ACS Applied Materials & Interfaces·Soraya Rasi GhaemiNicolas H Voelcker

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Methods Mentioned

BETA
X-ray
surface
atomic force microscopy
light microscopy
AFM

Software Mentioned

Eigenvector PLS Toolbox
cdk
R
rcdk
SMILES
[UNK]

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