PMID: 6991952Jun 5, 1980Paper

Analysis and prediction of protein beta-sheet structures by a combinatorial approach

Nature
F E CohenW R Taylor

Abstract

Analysis of beta-sheet sandwiches (for example immunoglobulin domains) suggests an algorithm that successfully predicts the tertiary fold of these proteins from their sequence and secondary structure. We propose tertiary structures for beta 2-microglobulin and an HLA-B7 antigen fragment. Topological rules are presented that markedly reduce the number of folds for proteins in which a-helices pack against a parallel beta-sheet.

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Aug 1, 1997·Protein Science : a Publication of the Protein Society·A Su, S L Mayo
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