PMID: 9160432Jan 1, 1997Paper

Analysis and significance of anti-nuclear antibodies in dogs

Research in Veterinary Science
S C BellS D Carter

Abstract

Assays for detecting and measuring antinuclear antibodies (ANA) in dogs were compared. They included the indirect immunofluorescence test, using rat liver as substrate, and ELISAs for three nuclear antigens: double-stranded DNA, single-stranded DNA, and histone. There was no correlation between the ANA titre and antibodies to the three nuclear antigens. Analysis of ANA in different arthropathies showed no specific disease association. HEP-2 cells showed no fluorescence reaction with either ANA-positive or ANA-negative dog sera. Western blotting produced too complex a pattern to identify specific antigens. The antigens that reacted with ANA in dogs were not identified; there is either a broad range of reactivities or non-specific binding of immunoglobulins.

References

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Citations

Oct 3, 1999·Veterinary Immunology and Immunopathology·S D CarterW H Gilmore
Nov 9, 2015·Veterinary Immunology and Immunopathology·Hanna D BremerHelene Hansson-Hamlin
Jan 20, 2006·Reproduction in Domestic Animals = Zuchthygiene·S Schäfer-SomiS Aslan
Jun 21, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·P J Ginel, R Lucena
Jan 12, 2021·JFMS Open Reports·Romain HuvéBérénice Conversy

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