Analysis and simulation of gain control and precision in crayfish visual interneurons

Journal of Neurophysiology
Raymon M Glantz, John P Schroeter

Abstract

Impulse trains in sustaining and dimming fibers of crayfish optic lobe (in situ) were elicited with sinusoidal extrinsic current and sine-wave illumination. Extrinsic currents and currents derived from postsynaptic potentials (PSPs) were used to compute the time course of the spike train with an adaptive integrate-and-fire model. The neurons exhibit variations in gain and spike timing precision related to the frequency of stimulation. These phenomena are influenced by spike-frequency adaptation and nonlinearities in the PSP. Dimming fibers exhibit relatively strong spike-frequency adaptation and an associated increase in gain with the frequency of sinusoidal extrinsic current and sine-wave illumination. The dimming fiber IPSP promotes spike train rectification, and rectification contributes to spike timing precision. Sustaining fibers exhibit weaker spike-frequency adaptation and the gain of the current-elicited response is less sensitive to stimulus frequency. The sustaining fiber excitatory PSP, however, exhibits a strong frequency-dependent nonlinearity that influences the frequency response. Spike timing precision is a function of stimulus frequency in all cells and it is enhanced by rectification of the discharge and/or re...Continue Reading

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Citations

Jul 11, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Raymon M Glantz, John P Schroeter
Dec 5, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Raymon M Glantz, John P Schroeter
Dec 29, 2010·PLoS Computational Biology·Tilo SchwalgerBenjamin Lindner
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marina S KuznetsovaWilliam J Spain
Jun 27, 2012·The Journal of Physiology·Tara DeemyadMaurice J Chacron

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