Analysis by UPLC-MS-QTOF and antifungal activity of guava (Psidium guajava L.)

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Camila Fonseca BezerraMaria Flaviana B Morais-Braga

Abstract

Psidium guajava L. is a plant widely used for food and in folk medicine all over the world. Studies have shown that guava leaves have antifungal properties. In this study, Flavonoid and Tannic fractions were tested to investigate their chemical composition and antifungal potential in vitro.21 compounds in the two fractions, presenting a higher content of phenolic compounds. The antifungal assays were performed against Candida albicans, Candida tropicalis and Candida krusei by microdilution to determine the IC50 and the cell viability curve. Minimal Fungicidal Concentration(MFC) and the inhibitory effects of the association of the fractions with Fluconazole, as well as the assays used to verify any morphological changes were performed in microculture chambers based on the concentrations from the microdilution. The IC50 of the isolated fractions and the fractions associated with each other were calculated, varying from 69.29 to 3444.62 μg/mL and the fractions associated with fluconazole varied from 925.56 to 1.57 μg/mL, it was clear that the association of the natural product with the antifungal presented a synergism. The fractions affected pleomorphism capacity and have a potential antifungal activity as they caused fungal inhib...Continue Reading

Citations

Jul 2, 2020·Infection and Drug Resistance·Manuela Gómez-Gaviria, Héctor M Mora-Montes
Nov 4, 2020·Journal of the Science of Food and Agriculture·Dingfa WangGuanyu Hou

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