Analysis of 24-hour blood pressure data

Journal of Biopharmaceutical Statistics
B RoddaL Capece

Abstract

Blood pressure is not constant over the course of a 24-h period, but exhibits a predictable and characteristic rise and decline during the day. Although the general shape of this pattern is similar from patient to patient, the knowledge of an individual's blood pressure at one or two points on this curve is of no predictive value in estimating the remainder of the curve. Since critical events are associated with both the maximum and minimum blood pressures that an individual experiences, a characterization of this curve can be very important. The development of antihypertensive agents historically presumed that the reduction in blood pressure associated with therapy would be, if not constant, at least adequate throughout the entire period. However, with the advent of less frequent dosing, the importance of assuring that blood pressure was adequately controlled over the 24-h period became important. This created interest in two basic types of comparisons. One is the comparison of dosing regimens, e.g., comparing a once-a-day regimen with a twice-a-day regimen. The second is a comparison of two therapies with the same regimen; for example, two doses designed to be administered twice a day. The shape of the curves in the first cas...Continue Reading

Citations

Apr 9, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gary A BoormanRichard D Irwin

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