Analysis of 24-hour urine parameters as it relates to age of onset of cystine stone formation

Journal of Endourology
Erica H LambertNicole L Miller

Abstract

Cystinuria is an inherited disorder characterized by the impaired reabsorption of the dibasic amino acid, cystine, in the proximal tubule of the nephron. Cystine stones most frequently occur in the first through third decades of life with a decreased incidence in old age. We hypothesize that patients presenting with first stone event at an older age would have more favorable 24-hour urine parameters compared with those patients who present early. This is a retrospective review of 94 patients with cystinuria and cystine stones who underwent a 24-hour urine test. The patients were divided into four groups based on age at first clinical stone event: group 1, children aged <18 years (n = 37); group 2, 18 to 32 years (n = 19); group 3, 33 to 50 years (n = 19); and group 4, >50 years (n = 19). All 24-hour urines were collected prior to any medical therapy. Statistical analysis was performed using analysis of variance and Tukey pairwise comparison test. There was a significant increase in cystine supersaturation (SS) for the young adults (group 2) as opposed to older adults (groups 3 and 4) though cystine excretion was not different among the groups. A higher urine volume appeared to account for the lower cystine SS in the older adult...Continue Reading

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Citations

Jan 22, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vidar O EdvardssonRunolfur Palsson
Mar 26, 2014·Nature Reviews. Urology·Kay ThomasAngela Doherty
Jun 19, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Chih-Jen Cheng, Shih-Hua Lin
Aug 3, 2012·Urology·Mohamed A Elkoushy, Sero Andonian
Dec 22, 2015·Case Reports in Radiology·William E HaleyCynthia H McCollough
Oct 17, 2015·Semergen·I Miguéns BlancoL García Méndez
May 31, 2018·International Urology and Nephrology·Saritha RanabothuBeth A Drzewiecki
Sep 13, 2020·Kidney International·Aude ServaisUNKNOWN Metabolic Nephropathy Workgroup of the European Reference Network for Rare Kidney Diseases (ERKNet) and eUROGEN
Apr 4, 2021·Journal of Clinical Medicine·Toshifumi TakahashiHitoshi Yamada
Aug 15, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ruth J Pepper, Richard S Trompeter

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Methods Mentioned

BETA
urine collections

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