Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A

Transplantation
William S OettingDeKAF Genomics and GEN03 Investigators

Abstract

Identifying kidney allograft recipients who are predisposed to acute rejection (AR) could allow for optimization of clinical treatment to avoid rejection and prolong graft survival. It has been hypothesized that a part of this predisposition is caused by the inheritance of specific genetic variants. There are many publications reporting a statistically significant association between a genetic variant, usually in the form of a single-nucleotide polymorphism (SNP), and AR. However, there are additional publications reporting a lack of this association when a different cohort of recipients is analyzed for the same single-nucleotide polymorphism. In this report, we attempted to validate 75 common genetic variants, which have been previously reported to be associated with AR, using a large kidney allograft recipient cohort of 2390 European Americans and 482 African Americans. Of those variants tested, only 1 variant, rs2910164, which alters the expression of the microRNA MIR146A, was found to exhibit a significant association within the African American cohort. Suggestive variants were found in the genes CTLA and TLR4. Our results show that most variants previously reported to be associated with AR were not validated in our cohort....Continue Reading

References

Jul 20, 1999·Kidney International·D SankaranI V Hutchinson
Dec 31, 2002·Journal of the American Society of Nephrology : JASN·Stefan HeidenreichUlrike Nowak-Göttl
Jun 27, 2003·Transplantation Proceedings·A MorgunM Gerbase-DeLima
Sep 17, 2004·Transplantation·Fang F YuanJeremy R Chapman
May 11, 2005·Kidney International·Didier DuclouxPierre Tiberghien
Jun 21, 2005·Transplantation Proceedings·A PawlikB Gawronska-Szklarz
Apr 7, 2006·Cell Biochemistry and Function·Bulent YigitTurgay Isbir
Nov 15, 2006·Clinical Transplantation·Steven ParaskevasArthur J Matas
May 10, 2007·Clinical Transplantation·Bernd KrügerBernhard K Krämer
Sep 14, 2007·Clinical Pharmacology and Therapeutics·J WangG J Burckart
Jan 1, 2008·Molecular and Cellular Biochemistry·Parmeet Kaur Manchanda, Rama Devi Mittal
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SolezM Valente
May 1, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Josep GrinyóLaurent Essioux
May 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Krystian JazdzewskiAlbert de la Chapelle
Oct 23, 2008·Current Opinion in Nephrology and Hypertension·Alexander S Goldfarb-Rumyantzev, Natalie Naiman
Nov 1, 2008·Bioinformatics·Andrew D JohnsonPaul I W de Bakker
Dec 11, 2008·Basic & Clinical Pharmacology & Toxicology·Lina QuteinehLaurent Becquemont
Jun 30, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ran-hui ChaYon Su Kim
Aug 16, 2011·Transplantation Proceedings·S J ParkY H Kim
Sep 17, 2011·Human Genetics·Nicolas Pallet, Eric Thervet
Oct 1, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·William S OettingUNKNOWN DeKAF Investigators
Jan 3, 2012·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Joanna PazikJacek Malejczyk
Dec 18, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E L D de Mare-BredemeijerJ Kwekkeboom
Dec 10, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Maneesh Kumar MisraSuraksha Agrawal
Dec 26, 2013·Transplant Immunology·Andrzej PawlikLeszek Domanski

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Citations

Feb 16, 2019·Transplantation·Elisabet Van Loon, Maarten Naesens
Dec 6, 2020·Current Opinion in Organ Transplantation·Claire TinelDany Anglicheau
Feb 11, 2021·Transplantation Direct·Rohan S PaulMuralidaran Jagadeesan
Jan 14, 2021·Transplantation Direct·Ehsan NobakhtSherry Dadgar
Jul 14, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Hidenao KayawakeHiroshi Date
Dec 11, 2021·Transplantation·Rokhaya BaSophie Limou

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