PMID: 2495275Apr 1, 1989Paper

Analysis of a common-antigen lipopolysaccharide from Pseudomonas aeruginosa

Journal of Bacteriology
M Rivera, E J McGroarty

Abstract

Lipopolysaccharide isolated from Pseudomonas aeruginosa PAO1 (O5 serotype) was separated into two antigenically distinct fractions. A minor fraction, containing shorter polysaccharide chains, reacted with a monoclonal antibody to a P. aeruginosa common antigen but did not react with antibodies specific to O5-serotype lipopolysaccharide. In contrast, fractions containing long polysaccharide chains reacted only with the O5-specific monoclonal antibodies. The shorter, common-antigen fraction lacked phosphate and contained stoichiometric amounts of sulfate, and the fatty acid composition of this fraction was similar to that of the O-antigen-specific fraction. The lipid A derived from the serotype-specific lipopolysaccharide cross-reacted with monoclonal antibodies against lipid A from Escherichia coli, while the lipid A derived from the common antigen did not react. We propose that many serotypes of P. aeruginosa produce two chemically and antigenically distinct lipopolysaccharide molecules, one of which is a common antigen with a short polysaccharide and a unique core-lipid A structure.

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Citations

May 15, 2002·FEMS Microbiology Reviews·Inge Lerouge, Jos Vanderleyden
Sep 27, 2002·Applied and Environmental Microbiology·R Sean NormanPamela J Morris
Aug 30, 2002·Applied and Environmental Microbiology·Anton A KorenevskyTerry J Beveridge
Dec 1, 1996·Trends in Microbiology·J B Goldberg, G B Pler
Sep 1, 1996·Progress in Lipid Research·S G Wilkinson
Sep 8, 1999·Microbiology and Molecular Biology Reviews : MMBR·H L RocchettaJ S Lam
Dec 1, 1995·Infection and Immunity·G B Pier, J B Goldberg
Mar 1, 1993·The International Journal of Biochemistry·M ChristofidouE D Anastassiou
Dec 1, 1991·Microbiological Reviews·T J Beveridge, L L Graham
Jul 6, 2016·ACS Chemical Biology·Mohammad M MohammadLiviu Movileanu

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