Analysis of a human gene homologous to rat ventral prostate.1 protein

Genomics
R E PeacockC F Inglehearn

Abstract

We report on the analysis of a human gene homologous to the rat ventral prostate.1 protein (RVP.1), which is transcriptionally induced in the regressing rat prostate after castration. EST database searching and Northern blotting reveal that this is one of at least four different members of a gene family in the human genome that produce transcripts of 3.4, 2.4, 1.9, and 1.2 kb, expressed in a wide range of tissues. Three other members of this gene family have already been mapped to chromosomes 7q, 17p, and 22q and reported either as anonymous ESTs or as full-length clones. We have now characterized a fourth member (assigned the gene now characterized a fourth member (assigned the gene name C7orf1 by GDB) and localized it also to chromosome 7q. C7orf1 is almost identical over much of its length to the reported ORF of RVP.1 while the other family members are more divergent from RVP.1. The genomic sequence of C7orf1 is intron-less, is spanned by a CpG low-methylation island, and has two noncoding, nonpolymorphic STR regions immediately adjacent to the open reading frame, one 5' and one 3'. The presence of a NotI restriction site in the coding sequence results in a deficiency in the IMAGE cDNA libraries, as a result of which the 3' ...Continue Reading

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Citations

Sep 4, 2003·Human Molecular Genetics·M Tassabehji
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·K MoritaS Tsukita
Jul 12, 2002·Kidney International·Jose Luis ReyesLorenza González-Mariscal
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Nov 19, 2013·Apoptosis : an International Journal on Programmed Cell Death·Pu XiaYang Bai
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Jan 5, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Malgorzata KapralLudmila Weglarz
Feb 8, 2019·Critical Reviews in Food Science and Nutrition·Imam HossenXiao Junsong
May 26, 2004·Journal of Cell Science·Kursad Turksen, Tammy-Claire Troy

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