Analysis of a new best-practice advisory on time to initiation of antibiotics in surgical intensive care unit patients with septic shock

Journal of the Intensive Care Society
Tyler ChanasStephanie Mallow-Corbett

Abstract

Early administration of antibiotics in septic shock is associated with decreased mortality. Promptly identifying sepsis and eliciting a response are necessary to reduce time to antibiotic administration. A best-practice advisory was introduced in the surgical intensive care unit to identify patients with septic shock and promote timely action. The best-practice advisory is triggered by blood culture orders and vasopressor administration within 24 h. The nurse or provider who triggers the alert may send an automatic notification to the intensive care unit resident, clinical pharmacist, and charge nurse, prompting bedside response and closer evaluation. Patients who met best-practice advisory criteria in the surgical intensive care unit from May 2016 through March 2017 were included. Outcomes included changes in antibiotics within 24 h, response to best-practice advisory, and time-to-antibiotics. Time-to-antibiotics was compared between a retrospective pre-intervention period and a six-month prospective post-intervention period defined by launch of the new best-practice advisory in September 2016. Data were analyzed by chi square, Mann-Whitney U, and Kruskal-Wallis. During the first six months of best-practice advisory implementa...Continue Reading

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Citations

Aug 15, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Laura Y SueAngela M Leung
May 19, 2021·BMJ Quality & Safety·Madoka HayashiGenie Roosevelt
Jul 29, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Courtney J BausNasia Safdar

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Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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