PMID: 6982749Dec 1, 1982Paper

Analysis of acid esterase activity and polymorphism as an aid for the classification of human low-grade malignant non-Hodgkin's lymphomas

Cancer
M R ParwareschH J Radzun

Abstract

Investigating a link between enzyme histochemical and recent immunohistochemical results, the authors studied the activity and the polymorphism of acid esterase (EC 3.1.1.6) in well defined human B-cell lymphomas. TWelve cases of chronic B-lymphocytic leukemia, 18 cases of centroblastic/centrocytic follicular lymphoma, and 17 cases of lymphoplasmacytic/lymphoplasmacytoid lymphoma, as diagnosed according to Kiel classification, were subjected to enzyme assay and isoelectric focusing of acid esterase. Enzyme values revealed no characteristic distribution among the lymphoma entities. The isoenzyme pattern, specific to normal human B-lymphocytes, were regularly detectable in all lymphoma entities. The results document the B-cell origin of the analyzed subsets of B-cell malignancies, although distinctive acid esterase patterns were lacking. The prevalence of three anodal isoenzymes in cases of chronic B-lymphocytic leukemia, hardly detectable in other lymphoma entities, were interpreted as the expression of a clonal proliferation, arrested at a certain differentiation stage of B-cells common for the majority of the tumor cells. Hence, further evidence is provided supporting the view that the studied entities represent B-cell neoplas...Continue Reading

References

Dec 1, 1979·American Journal of Clinical Pathology·G P de VriesG T Sanders
Oct 1, 1979·American Journal of Clinical Pathology·L Kass, D Munster
Jun 1, 1977·British Journal of Haematology·J KulenkampffM F Greaves
Mar 1, 1979·American Journal of Clinical Pathology·C M WoodruffS A Stass
May 1, 1979·American Journal of Clinical Pathology·F NaeimR A Gatti
Jan 26, 1972·Biochimica Et Biophysica Acta·O Vesterberg
May 9, 1972·Biochimica Et Biophysica Acta·E FerberW Imm
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Sep 15, 1981·Cellular Immunology·H J RadzunJ W Wittke
Mar 28, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·H J RadzunH Stein
Jul 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·H J RadzunA C Feller
Aug 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H SteinJ Gerdes

❮ Previous
Next ❯

Citations

Aug 1, 1984·European Journal of Pediatrics·G Gaedicke, H G Drexler
Aug 1, 1986·The Histochemical Journal·H KreipeM R Parwaresch
Jan 1, 1991·Leukemia & Lymphoma·H G DrexlerJ Minowada
Jan 1, 1985·Leukemia Research·H G DrexlerJ Minowada
Dec 1, 1985·European Journal of Cancer & Clinical Oncology·H G DrexlerJ Minowada
Feb 15, 1983·International Journal of Cancer. Journal International Du Cancer·H J RadzunM Eissner

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.