PMID: 12787258Jun 6, 2003Paper

Analysis of adenosine vascular effect in isolated rat aorta: possible role of Na+/K+-ATPase

Pharmacology & Toxicology
L Grbović, M Radenković

Abstract

The present experiments were undertaken in order to examine the effect of adenosine in isolated rat aorta, to investigate the possible role of intact endothelium and endothelial relaxing factors in this action and to determine which population of adenosine receptors is involved in rat aorta response to adenosine. Adenosine (0.1-300 microM) produced concentration-dependent (intact rings: pD2=4.39+/-0.09) and endothelium-independent (denuded rings: pD2=4.52+/-0.12) relaxation of isolated rat aorta. In the presence of high concentration of K+ (100 mM) adenosine-evoked relaxation was significantly reduced (maximal relaxation in denuded rings: control - 92.1+/-9.8 versus K+- 54.4+/-5.0). Similar results were obtained after incubation of ouabain (100 microM) or glibenclamide (1 microM). In K+-free solution, K+ (1-10 mM)-induced rat aorta relaxant response was significantly inhibited by ouabain (100 microM). Application of indomethacin (10 microM), NG-nitro-L-arginine (10 microM) or tetraethylammonium (500 microM) did not alter the adenosine-elicited effect in rat aorta. 8-(3-Chlorostyril)-caffeine (0.3-3 microM), a selective A2A-receptor antagonist, significantly reduced adenosine-induced relaxation of rat aorta in a concentration-de...Continue Reading

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Citations

Sep 15, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Dovenia S PonnothS Jamal Mustafa
Mar 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Dovenia S PonnothS Jamal Mustafa
Sep 29, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dovenia S PonnothS Jamal Mustafa
Dec 14, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dovenia S PonnothS Jamal Mustafa
Aug 21, 2013·Pharmacological Reports : PR·Miroslav RadenkovićMilica Stojiljković
Sep 14, 2010·Biochimica Et Biophysica Acta·Dovenia S Ponnoth, S Jamal Mustafa
Aug 26, 2004·American Journal of Physiology. Renal Physiology·Xuemei WangRodger Loutzenhiser
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·M Verónica DonosoJ Pablo Huidobro-Toro
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Oct 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Habib R AnsariS Jamal Mustafa

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