Analysis of adult 20-year survivors after liver transplantation

Hepatology International
C DopazoR Charco

Abstract

Liver transplantation (LT) is the treatment of choice for chronic and acute liver failure; however, the status of long-term survivors and allograft function is not well known. To evaluate the clinical outcome and allograft function of survivors 20 years post-LT, cause of death during the same period and risk factors of mortality. A retrospective study was conducted from prospective, longitudinal data collected at a single center of adult LT recipients surviving 20 years. A comparative sub-analysis was made with patients who were not alive 20 years post-transplantation to identify the causes of death and risk factors of mortality. Between 1988 and 1994, 132 patients received 151 deceased-donors LT and 28 (21%) survived more than 20 years. Regarding liver function in this group, medians of AST, ALT and total bilirubin at 20 years post-LT were 33 IU/L (13-135 IU/L), 27 (11-152 IU/L) and 0.6 mg/dL (0.3-1.1 mg/dL). Renal dysfunction was observed in 40% of patients and median eGFR among 20-year survivors was 64 mL/min/1.73 m(2) (6-144 mL/min/1.73 m(2)). Sixty-one percent of 20-year survivors had arterial hypertension, 43% dyslipidemia, 25% de novo tumors and 21% diabetes mellitus. Infections were the main cause of death during the 1s...Continue Reading

References

Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
May 15, 1996·Transplantation·S AsfarW Wall
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
May 5, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R CharcoC Margarit
Jul 13, 2001·American Journal of Surgery·J M RabkinA J Olyaei
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Satheesh NairPaul J Thuluvath
Jun 5, 2003·Journal of Hypertension·UNKNOWN European Society of Hypertension-European Society of Cardiology Guidelines Committee
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Jan 6, 2004·Clinical Transplantation·Itxarone BilbaoCarlos Margarit
Dec 13, 2006·International Immunopharmacology·Itxarone BilbaoCarlos Margarit
Nov 23, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Robert PfitzmannPeter Neuhaus
Jan 15, 2008·Clinical Transplantation·Tadahiro UemuraGoran B Klintmalm
Oct 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Fredrik AbergHelena Isoniemi
Dec 3, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P BurraF Villamil
Dec 26, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Javier BriceñoPedro López-Cillero
Sep 1, 2009·Transplantation Proceedings·I BilbaoR Charco
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J Ignacio Herrero
May 27, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Shireena DesaiSammy Saab
Apr 13, 2011·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·F ÅbergK Höckerstedt
Jan 12, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M F AbdelmalekUNKNOWN Sirolimus Liver Conversion Trial Study Group
May 23, 2012·Journal of Hepatology·René AdamUNKNOWN European Liver and Intestine Transplant Association (ELITA)
Aug 14, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P De SimoneUNKNOWN H2304 Study Group
Mar 13, 2013·Journal of the American College of Surgeons·Abbas RanaRonald W Busuttil
May 30, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Angel RubínMarina Berenguer
Jul 3, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·C Kristian EnestvedtAbraham Shaked
Aug 7, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W N SchoeningP Neuhaus

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Citations

Mar 31, 2015·Hepatology International·Russell Strong, Jonathan Fawcett
Mar 25, 2016·World Journal of Transplantation·Arnav Agarwal, G V Ramesh Prasad
Dec 17, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J MartinelliO Bernard
May 17, 2019·European Journal of Gastroenterology & Hepatology·Aafke A DuizendstraJaap Kwekkeboom
Jul 21, 2020·Expert Review of Gastroenterology & Hepatology·Nicholas Hoppmann, Omar Massoud
Apr 23, 2017·Current Treatment Options in Gastroenterology·Brian C Davis, M Shadab Siddiqui
Mar 31, 2017·World Journal of Hepatology·Sven PischkeMartina Sterneck
Jul 17, 2020·Frontiers in Immunology·Xiaoxiao DuZhonghua Klaus Chen
Dec 6, 2020·Current Opinion in Organ Transplantation·Stela Celaj, Josh Levitsky
May 16, 2020·Transplantation Proceedings·Sara KimKyung-Suk Suh
Jun 4, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Aafke A DuizendstraNicolle H R Litjens

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