Analysis of adverse events of renal impairment related to platinum-based compounds using the Japanese Adverse Drug Event Report database

SAGE Open Medicine
Misa NaganumaMitsuhiro Nakamura

Abstract

Platinum compounds cause several adverse events, such as nephrotoxicity, gastrointestinal toxicity, myelosuppression, ototoxicity, and neurotoxicity. We evaluated the incidence of renal impairment as adverse events are related to the administration of platinum compounds using the Japanese Adverse Drug Event Report database. We analyzed adverse events associated with the use of platinum compounds reported from April 2004 to November 2016. The reporting odds ratio at 95% confidence interval was used to detect the signal for each renal impairment incidence. We evaluated the time-to-onset profile of renal impairment and assessed the hazard type using Weibull shape parameter and used the applied association rule mining technique to discover undetected relationships such as possible risk factor. In total, 430,587 reports in the Japanese Adverse Drug Event Report database were analyzed. The reporting odds ratios (95% confidence interval) for renal impairment resulting from the use of cisplatin, oxaliplatin, carboplatin, and nedaplatin were 2.7 (2.5-3.0), 0.6 (0.5-0.7), 0.8 (0.7-1.0), and 1.3 (0.8-2.1), respectively. The lower limit of the reporting odds ratio (95% confidence interval) for cisplatin was >1. The median (lower-upper quar...Continue Reading

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Citations

Nov 7, 2019·Biological & Pharmaceutical Bulletin·Go AndoKazuaki Matsumoto
Dec 24, 2018·Journal of Pharmaceutical Health Care and Sciences·Haruna HatahiraMitsuhiro Nakamura
Apr 28, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Hitomi FujishiroSeiichiro Himeno

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