Analysis of alpha1-adrenoceptors in rabbit lower urinary tract and mesenteric artery

European Journal of Pharmacology
P H Van der GraafI Angel

Abstract

In this study, we have investigated the effects of a series of alpha1-adrenoceptor antagonists on the phenylephrine-mediated contractions of rabbit isolated prostate, urethra, trigone and mesenteric artery. With the exception of RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha,alpha-dim ethyl-1 H-indole-3-ethanamine hydrochloride), the antagonists displayed the lowest potency in the urethra. Catecholamine uptake1 and uptake2 appeared not to be the cause for the low pK(B)/pA2 values obtained in the urethra because cocaine and corticosterone had no effect on the potency of phenylephrine in this tissue. The low potencies displayed by prazosin. RS-17053 and HV723 (alpha-ethyl-3,4,5-trimethoxy-alpha-(3-((2-(2-methoxyphenoxy)ethyl)amino )propyl)benzene-acetonitrile fumarate) suggest that the functional receptors in all four tissues belong to the alpha(1L)-adrenoceptor class. Whether or not the significant between-tissue differences in antagonist potencies are due to heterogeneity of this receptor class remains to be elucidated.

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Citations

Mar 4, 1999·European Journal of Pharmacology·Y HiraokaI Muramatsu
Jul 13, 1999·British Journal of Pharmacology·W B StamP R Saxena
Sep 13, 2013·British Journal of Pharmacology·Hatsumi YoshikiIkunobu Muramatsu
Jul 13, 2011·British Journal of Pharmacology·A NishimuneI Muramatsu
Feb 9, 2006·British Journal of Pharmacology·Martin C Michel, Wim Vrydag
Oct 21, 2016·Indian Journal of Pharmacology·Ipsita MohantySubas Chandra Parija
Sep 14, 2006·Autonomic & Autacoid Pharmacology·K Bagot, R Chess-Williams
Aug 22, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Atsushi NishimuneIkunobu Muramatsu
Feb 16, 2017·The Journal of Pharmacology and Experimental Therapeutics·Dorathy-Ann HarrisChris Hague
Jan 24, 2002·The Journal of Pharmacology and Experimental Therapeutics·Arthur A HancockMichael Williams
Aug 13, 2008·British Journal of Pharmacology·T-H SuI Muramatsu
Jan 3, 2001·Medicinal Research Reviews·C E HillS L Sandow
May 27, 2009·British Journal of Pharmacology·I MuramatsuS Morishima

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