Analysis of amino acid variation in the P2 domain of the GII-4 norovirus VP1 protein reveals putative variant-specific epitopes.

PloS One
David J AllenMiren Iturriza-Gómara

Abstract

Human noroviruses are a highly diverse group of viruses classified into three of the five currently recognised Norovirus genogroups, and contain numerous genotypes or genetic clusters. Noroviruses are the major aetiological agent of endemic gastroenteritis in all age groups, as well as the cause of periodic epidemic gastroenteritis. The noroviruses most commonly associated with outbreaks of gastroenteritis are genogroup II genotype 4 (GII-4) strains. The relationship between genotypes of noroviruses with their phenotypes and antigenic profile remains poorly understood through an inability to culture these viruses and the lack of a suitable animal model. Here we describe a study of the diversity of amino acid sequences of the highly variable P2 region in the major capsid protein, VP1, of the GII-4 human noroviruses strains using sequence analysis and homology modelling techniques. Our data identifies two sites in this region, which show significant amino acid substitutions associated with the appearance of variant strains responsible for epidemics with major public health impact. Homology modelling studies revealed the exposed nature of these sites on the capsid surface, providing supportive structural data that these two sites ...Continue Reading

References

Mar 1, 1990·Journal of Clinical Microbiology·R BoomJ van der Noordaa
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K F Lau, K A Dill
Apr 25, 1990·Nucleic Acids Research·R BoomP Wertheim-van Dillen
Feb 17, 1968·Nature·M Kimura
Jan 1, 1997·Annual Review of Microbiology·E Domingo, J J Holland
Oct 9, 1999·Science·B V PrasadM K Estes
May 11, 2000·The Journal of Infectious Diseases·A W MountsR I Glass
Aug 31, 2002·Virology·Kazuhiko KatayamaNaokazu Takeda
Jan 21, 2003·Emerging Infectious Diseases·Benjamin A LopmanDavid W G Brown
Oct 27, 2004·Emerging Infectious Diseases·Ben A LopmanJoyshri Sarangi
Mar 30, 2005·Journal of Virology·Jacques RohayemAxel Rethwilm
Jul 19, 2005·Emerging Infectious Diseases·Rowena A BullPeter A White
Sep 28, 2005·The Journal of General Virology·Vance P LochridgeMichele E Hardy
Oct 7, 2005·Journal of Clinical Microbiology·K Ambert-BalayE Kohli
Jul 5, 2007·Journal of Virology·J Joukje SiebengaMarion Koopmans
Oct 19, 2007·Journal of Clinical Microbiology·W E AdamsonW F Carman

❮ Previous
Next ❯

Citations

Sep 18, 2009·Journal of Virology·Karin BokKim Y Green
Apr 3, 2010·PLoS Pathogens·Rowena A BullPeter A White
Jul 16, 2010·Journal of Clinical Microbiology·Vipin Kumar MenonGagandeep Kang
Oct 29, 2010·Journal of Virology·Lisa C LindesmithRalph S Baric
Jun 15, 2011·Applied and Environmental Microbiology·Ilaria Di BartoloFranco Maria Ruggeri
Dec 30, 2011·Journal of Virology·Rowena A BullPeter A White
May 23, 2012·PLoS Pathogens·Lisa C LindesmithRalph S Baric
Aug 3, 2013·The Journal of Infectious Diseases·Kari DebbinkRalph S Baric
Jul 4, 2012·Virus Genes·Gyu-Cheol LeeChan Hee Lee
Feb 9, 2012·Epidemiology and Infection·G McAllisterK E Templeton
Aug 30, 2008·Current Opinion in Infectious Diseases·Marion Koopmans
Nov 6, 2010·Archives of Virology·Tae-Hee HanEung-Soo Hwang
Apr 20, 2012·Expert Review of Anti-infective Therapy·Andrew Kirby, Miren Iturriza-Gómara
Feb 3, 2016·Human Vaccines & Immunotherapeutics·Nada M Melhem
Oct 5, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·John-Sebastian EdenPeter A White
Sep 25, 2009·The Journal of Hospital Infection·M Koopmans
Feb 24, 2009·Veterinary Microbiology·Axel MauroyEtienne Thiry
Sep 7, 2013·Journal of Medical Virology·Wisoot Chan-ItHiroshi Ushijima
May 21, 2015·Journal of Medical Virology·Tatsuya MiyoshiTomoyuki Tanaka
Dec 2, 2008·Journal of Medical Virology·Zornitsa MladenovaUNKNOWN Norovirus Study Group
Oct 8, 2008·Immunological Reviews·Eric F DonaldsonRalph S Baric
Jan 17, 2012·Journal of Medical Virology·Nobuhiro IritaniYoshiyuki Seto
Aug 21, 2013·Reviews in Medical Virology·Nathalie Ruvoën-ClouetJacques Le Pendu
Jul 23, 2013·Journal of Medical Virology·Kun Lee LimPeter A White
May 16, 2012·Journal of Medical Virology·Wisoot Chan-ItHiroshi Ushijima
Dec 9, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Li GuoTao Hung
Aug 13, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maria Eugenia GaleanoJosé Paulo Leite
Feb 7, 2015·Journal of Medical Virology·Noelia Carmona-VicenteJavier Buesa
Feb 19, 2017·Archives of Virology·Taotao YangXinglong Yu
Aug 29, 2017·Human Vaccines & Immunotherapeutics·David J Allen, John P Harris
Dec 21, 2017·Frontiers in Microbiology·Takumi MotoyaHirokazu Kimura
May 30, 2014·Journal of Virology·Lisa C LindesmithRalph S Baric
Dec 28, 2012·Journal of Virology·Lisa C LindesmithRalph S Baric
Nov 18, 2011·Journal of Virology·Lisa C LindesmithEric F Donaldson

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
nucleic acid extraction

Software Mentioned

Deep View Swiss PDB Viewer
Deep View Swiss - PDB Viewer
YASARA
BioEdit

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Gábor ReuterGyörgy Szücs
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Elise T-V TuPeter A White
Gastroenterology Clinics of North America
Robert L Atmar, Mary K Estes
© 2021 Meta ULC. All rights reserved