Analysis of aminoacids pattern in receptor tyrosine kinase using Boolean association rule.

Bioinformation
Pranjal KalitaSenthil Kumar Nachimuthu

Abstract

Cancers are characterized by unrestricted cell division and independency of growth factor and other external signal responsiveness. Eukaryotic parental cells of tumors, on the other hand, constitute tissues and other higher structures like organs and systems and are capable of performing various functions in a highly co-ordinated fashion. Hence, cancer cells may be considered as entities capable of incessant growth and cell division but lacking any evolutionarily advanced intracellular or intercellular regulation. Since receptor tyrosine kinases are highly altered and exist in deregulated/constitutively active forms in cancer cells - achieved through various epigenetic mechanisms - we hypothesize the functional RTKs in cancer cells to resemble their counterparts in more primitive species. Analysis of RTK sequences of various species and of cancer is, therefore, expected to prove this hypothesis. Association rule in data mining can reveal the hidden biological information. This study utilizes the Boolean association rule to mine the occurrence pattern of glycine, arginine and alanine in receptor tyrosine kinases (RTKs) of invertebrates, vertebrates and cancer related vertebrate RTKs based on protein sequence informations. The re...Continue Reading

References

May 20, 1999·Carcinogenesis·M L RoseR G Thurman
Nov 1, 2000·Cell·J Schlessinger
May 4, 2004·Nature Reviews. Cancer·Andreas GschwindAxel Ullrich
Jun 3, 2004·Nature Reviews. Molecular Cell Biology·Stevan R Hubbard
Jul 2, 2004·The EMBO Journal·Kristi G BacheHarald Stenmark

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