PMID: 9185591May 26, 1997Paper

Analysis of an interaction between the soluble vaccinia virus-coded type I interferon (IFN)-receptor and human IFN-alpha1 and IFN-alpha2

Virology
H LiptákováP Kontsek

Abstract

The soluble B18R protein coded by vaccinia virus exerts properties of a type I interferon (IFN)-receptor with broad species specificity. We analyzed neutralizing and binding activity of the B18R protein against several recombinant human type I IFNs. The B18R protein inhibited the antiviral potency of IFN-alpha1, IFN-alpha2, IFN-alpha8/1/8, and IFN-omega on human cells. The N-terminal domain of human type I IFN is involved in the high affinity binding to its cellular receptor. To localize the binding domain(s) of IFN with the B18R protein, competition experiments between B18R, and mapped monoclonal antibodies to IFN-alpha1 and IFN-alpha2 were performed. Surprisingly, our data indicated that the contact area between the B18R protein and IFN comprised in addition to the N-terminal region of IFN-molecule also its C-terminal portion. We suggest that this different pattern of interaction with a ligand might determine the ability of B18R protein to bind type I IFNs of different species.

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Citations

Sep 26, 2007·Annals of the New York Academy of Sciences·Alyson J ManginiJean Maguire Van Seventer
Dec 20, 2007·The Journal of General Virology·Richard E Randall, Stephen Goodbourn
Aug 19, 2007·Immunologic Research·Matthew A Fischer, Christopher C Norbury
Aug 28, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Beatriz Perdiguero, Mariano Esteban
May 10, 2006·Cellular Microbiology·Akinori Takaoka, Hideyuki Yanai
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jiaying HuangSergei V Kotenko
Mar 14, 2012·Immunology and Cell Biology·Nicole A de Weerd, Thao Nguyen
Jan 2, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Seong-Heon WieChristopher H Woelk
Feb 23, 2013·Nature Protocols·Pankaj K Mandal, Derrick J Rossi
Feb 26, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Cari Fritz-FrenchWilliam R Tyor
Jan 25, 2003·Annual Review of Immunology·Bruce T SeetGrant McFadden
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E MizukoshiK Kobayashi
Jan 7, 1998·Immunological Reviews·G L SmithA Alcamí
Nov 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K E MogensenG Uzé
Oct 22, 2020·Cellular and Molecular Life Sciences : CMLS·José M RojasNoemí Sevilla

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