Abstract
Genetic polymorphisms are variations in DNA sequences which can influence either disease susceptibility, severity, or prognosis. Pulmonary arterial hypertension (PAH) is one of the complications that occurs in certain patients who have atrial septal defect (ASD). This study seeks to determine the association of gene polymorphisms with the pathogenesis of PAH in ASD patients. This study was conducted on 30 ASD patients with PAH, and 50 ASD patients who were not diagnosed with PAH. All respondents were Malay. Patients were selected based on stringent inclusion and exclusion criteria. Molecular analyses were done to detect the genetic polymorphisms of angiotensin converting enzyme (ACE I/D), serotonin transporter (5-HTTLPR), endothelial nitric oxide synthase (eNOS) G894T, and eNOS 4b/4a. The genotypes of these genetic polymorphisms were determined using conventional PCR and PCR-RFLP methods. The PCR products were analysed using agarose gel electrophoresis. Statistical analysis was done using SPSS Version 22. Clinical characteristics, such as the diameter of ASD, mean arterial pressure (MAP), and mean pulmonary artery pressure (mPAP) differed significantly (p < 0.05). Based on the statistical analysis, ACE I/D, eNOS G894T, and eNOS...Continue Reading
References
Jun 1, 1996·Journal of Neurochemistry·A HeilsK P Lesch
Nov 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Y WangA Koyama
Aug 4, 2001·Nitric Oxide : Biology and Chemistry·R AlvarezE Coto
Mar 18, 2003·Heart·M M HoeperR Lichtinghagen
Apr 15, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·William T AbrahamM Benjamin Perryman
Dec 20, 2003·Respiratory Medicine·Pinar YildizVeysel Yilmaz
Oct 23, 2004·Clinical Biochemistry·Aarif AhsanM A Qadar Pasha
May 7, 2005·Wiener klinische Wochenschrift·Ruzena TkácováIvan Kalina
Jul 13, 2005·Biochemical and Biophysical Research Communications·Akshaya Vachharajani, Scott Saunders
Dec 13, 2005·American Journal of Respiratory and Critical Care Medicine·Elisabeth D WillersJohn A Phillips
Jan 10, 2006·American Journal of Respiratory and Critical Care Medicine·Rajiv D MachadoBart Janssen
Feb 4, 2006·American Journal of Respiratory and Critical Care Medicine·Marc HumbertGérald Simonneau
Apr 15, 2006·Circulation Research·Christophe GuignabertSaadia Eddahibi
Oct 16, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kamna SrivastavaNibhriti Das
Jan 8, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Vasudevan RamachandranRusni Mohd Jas
Jun 27, 2009·Respiration; International Review of Thoracic Diseases·Silvia UlrichRudolf Speich
Jan 1, 2008·Annals of Thoracic Medicine·Robyn J Barst
Nov 6, 2009·Clinical and Experimental Hypertension : CHE·Hailong CaoYijiang Chen
Jan 19, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Sayed Mohammad ShafieeAhmad Mohebbi
Dec 2, 2010·European Respiratory Review : an Official Journal of the European Respiratory Society·B J M Mulder
Dec 20, 2011·Archivos de bronconeumología·Adolfo BaloiraDiana Valverde
Jun 26, 2013·Circulation. Heart Failure·Ryan J TedfordDavid A Kass
Sep 24, 2013·Molecular Biology Reports·Sevinc Sarinc UlasliFatma Belgin Atac
Oct 1, 2013·Metabolism: Clinical and Experimental·Hang ZhangRen-Yi Qin
Feb 6, 2014·PloS One·Jian-Quan LuoWei Zhang
Mar 6, 2015·Balkan Journal of Medical Genetics : BJMG·R VasudevanS Eshkor
May 11, 2016·Pulmonary Circulation·Anne Katrine Z JohansenMargaret R MacLean
May 18, 2016·Archives of Medical Science : AMS·Radosław MlakTeresa Małecka-Massalska
May 3, 2018·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Guodong XuWenquan Niu