PMID: 9189007Jan 1, 1997Paper

Analysis of antibody-dependent cell-mediated cytotoxicity in autoimmune thyroid disease

Autoimmunity
R A MetcalfeA Weetman

Abstract

There is no consensus on the role of antibody-dependent cell-mediated cytotoxicity (ADCC) in autoimmune thyroid disease; recent reports have suggested that antibodies mediating ADCC are found particularly in patients with primary myxoedema, occur less frequently in Hashimoto's thyroiditis and are absent in Graves' disease. Using an ADCC assay with a single source of effector and target cells, and expressing results as lytic units, we have found antibodies capable of mediating ADCC in 9 of 17 patients with primary myxoedema, 9 of 22 patients with Hashimoto's thyroiditis and 6 of 22 patients with Graves' disease. There was no significant difference between the groups in this distribution. Mean levels of ADCC activity were not significantly different comparing primary myxoedema and Hashimoto's thyroiditis patients, although levels were lower in Graves' disease patients compared to those with Hashimoto's thyroiditis (P < 0.05). There was no correlation between TPO antibodies (total IgG or IgG subclasses) measured by ELISA and ADCC activity. These results suggest that thyroid antigens besides TPO are involved in ADCC and that antibodies mediating ADCC are not restricted to subgroups of patients with autoimmune thyroid disease.

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Citations

Dec 24, 2008·World Journal of Pediatrics : WJP·Ben-Skowronek IwonaSzewczyk Leszek
Dec 29, 2000·International Reviews of Immunology·E A Stafford, N R Rose
Aug 11, 2012·Immunobiology·Sandra A RebuffatSylvie Peraldi-Roux
Sep 4, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Claus H NielsenLaszlo Hegedüs
May 10, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Raju V S R K GottumukkalaElizabeth Helen Kemp
Dec 13, 2007·The Journal of Clinical Endocrinology and Metabolism·Sandra A RebuffatSylvie Peraldi-Roux
May 22, 2019·Journal of Applied Research in Intellectual Disabilities : JARID·Carole Beighton, Jane Wills

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