Analysis of Approaches to Anti-tuberculosis Compounds

ACS Omega
Sara Motamen, Ronald J Quinn

Abstract

Mycobacterium tuberculosis (Mtb) remains a deadly pathogen two decades after the announcement of tuberculosis (TB) as a global health emergency by the World Health Organization. Medicinal chemistry efforts to synthesize potential drugs to shorten TB treatments have not always been successful. Here, we analyze physiochemical properties of 39 TB drugs and 1271 synthetic compounds reported in 40 publications from 2006 to early 2020. We also propose a new TB space of physiochemical properties that may provide more appropriate guidelines for design of anti-TB drugs.

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Citations

May 4, 2021·European Journal of Medicinal Chemistry·Valentina Nascimento Melo de OliveiraRonaldo Nascimento de Oliveira
Jul 22, 2021·Computational and Structural Biotechnology Journal·Alexander D H Kingdon, Luke J Alderwick
Aug 26, 2021·Computational and Structural Biotechnology Journal·Isin T SakalliogluRobert Powers

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