Analysis of arsenic compounds by capillary electrophoresis using indirect UV and mass spectrometric detections

Electrophoresis
Fumihiko KitagawaKoji Otsuka

Abstract

CE with indirect UV and mass-spectrometric detection was used for the simultaneous determination of arsenic acid (As(V)), arsenous acid (As(III)), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), trimethylarsine oxide (TMAO), tetramethylarsonium ion (TMA(+)), arsenobetaine (AB), and arsenocholine (AC). In the CE-indirect UV analysis, a baseline separation of arsenic species was successfully achieved by using a basic background solution (BGS) for anions and an acidic BGS for cations, respectively. The LOD values in CE-indirect UV for the individual analytes were 7.8, 12.5, 7.8, 12.5, 62.5, 125, 250, and 62.5 ppm, respectively. To achieve sensitive and selective analysis, CE coupled with ESI-MS was applied to the determination of arsenic compounds. The organic arsenic species were successfully separated with a higher sensitivity by CE-MS using the acidic BGS. The LODs in CE-MS for MMA, DMA, TMAO, TMA(+), AB, and AC were 1.0, 0.1, 0.01, 0.1, 0.01, and 0.01 ppm, respectively. In contrast, the analysis of inorganic arsenic species (As(V) and As(III)) resulted in a lower detectability in CE-MS compared to that obtained with the CE-indirect UV analysis. However, the speciation of eight arsenics by CE-MS was successfully achie...Continue Reading

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Citations

Dec 4, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Małgorzata Anita Bryszewska, Amund Måge
Jun 22, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Patricia M Taylor
Jul 28, 2012·Journal of Hazardous Materials·Rakesh N ShindeAshok K Pandey
Apr 3, 2007·Journal of Separation Science·Jafariah JaafarNobuo Tanaka
Feb 28, 2007·Journal of Mass Spectrometry : JMS
Dec 7, 2007·Electrophoresis·Franco Tagliaro, Federica Bortolotti
Dec 29, 2007·Electrophoresis·Andras GasparPhilippe Schmitt-Kopplin
Jul 2, 2010·Electrophoresis·Meng-Wei HsiehShiuh-Jen Jiang
Nov 21, 2007·Human & Experimental Toxicology·A VahidniaF A de Wolff

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