Analysis of association of clinical aspects and IL1B tagSNPs with severe preeclampsia

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Larissa Paes Leme GalvãoRicardo Gurgel

Abstract

This study investigates the association between IL1B genotypes using a tag SNP (single polymorphism) approach, maternal and environmental factors in Brazilian women with severe preeclampsia. A case-control study with a total of 456 patients (169 preeclamptic women and 287 controls) was conducted in the two reference maternity hospitals of Sergipe state, Northeast Brazil. A questionnaire was administered and DNA was extracted to genotype the population for four tag SNPs of the IL1Beta: rs 1143643, rs 1143633, rs 1143634 and rs 1143630. Haplotype association analysis and p-values were calculated using the THESIAS test. Odds ratio (OR) estimation, confidence interval (CI) and multivariate logistic regression were performed. High pregestational body mass index (pre-BMI), first gestation, cesarean section, more than six medical visits, low level of consciousness on admission and TC and TT genotype in rs1143630 of IL1Beta showed association with the preeclamptic group in univariate analysis. After multivariate logistic regression pre-BMI, first gestation and low level of consciousness on admission remained associated. We identified an association between clinical variables and preeclampsia. Univariate analysis suggested that inflamma...Continue Reading

References

Aug 1, 1990·American Journal of Obstetrics and Gynecology·A F SaftlasR Pokras
Jul 13, 1974·Lancet·G Teasdale, B Jennett
Aug 11, 1993·Nucleic Acids Research·L G LeeW Bloch
Nov 20, 1998·American Journal of Obstetrics and Gynecology·G A Dekker, B M Sibai
May 8, 2001·Obstetrics and Gynecology·L A HeflerA R Gregg
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Augusta M A LachmeijerLeo P ten Kate
Jun 22, 2002·JAMA : the Journal of the American Medical Association·Kristine Y Lain, James M Roberts
Oct 29, 2002·Lancet·Richard E LeachD Randall Armant
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Ellen W Seely, Caren G Solomon
Jul 10, 2003·Obstetrics and Gynecology·Baha M Sibai
Mar 1, 2005·Lancet·Baha SibaiMichael Kupferminc
Apr 22, 2005·Journal of Perinatal Medicine·Johannes Dietl
Jul 22, 2005·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Laura A Stokowski
Sep 15, 2005·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·José Guilherme CecattiMaria José Duarte Osis
Dec 8, 2005·Scandinavian Journal of Public Health·Ulf Högberg
Nov 6, 2007·Brazilian Dental Journal·Marisi Aidar, Sergio Roberto Peres Line
Apr 5, 2008·Current Opinion in Obstetrics & Gynecology·Baha M Sibai
Aug 25, 2012·Biochimica Et Biophysica Acta·Jiska JebbinkCarrie Ris-Stalpers
May 9, 2014·Obstetrics and Gynecology·Elizabeth W TricheJames F Padbury

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Citations

Sep 29, 2018·American Journal of Reproductive Immunology : AJRI·Ioannis BellosCharalampos Siristatidis
Jan 17, 2020·Molecular Genetics & Genomic Medicine·Hameed M HamidHamdan Z Hamdan
Jan 9, 2019·Frontiers in Physiology·Rafael Tomoya MichitaJosé Artur Bogo Chies
Jul 28, 2019·Biology of Reproduction·Kelsey M HirschiJuan A Arroyo
Nov 20, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Kristy R Howell, Theresa L Powell
Jul 20, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Fatemeh NasriBehrouz Gharesi-Fard

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