Analysis of attitudes toward the source of progenitor cells in tissue-engineered products for use in burns compared with other disease states

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Anthony J P CloverArun H S Kumar

Abstract

The first trials using progenitor cells to improve burn wound healing are beginning. However, there remains a paucity of data on patients' opinions of the source of stem cells. In this study, 279 patients attending plastic surgery/burns outpatient and medical outpatient clinics were questioned to assess willingness to accept a tissue-engineered skin product derived from a variety of sources. Levels of acceptance for the use of progenitor cells derived from these sources for treatment across a range of disease states (burns, Parkinson's disease, diabetes, and for cosmetic use) were also assessed. Overall, 80% of those questioned would accept a tissue-engineered product. Autologous cells were the preferred choice of cells (acute burns 94%, diabetes 95%, Parkinson's 93.9%). Allogeneic cells were still widely accepted (acute burns 67%, diabetes 66.7%, Parkinson's 69.2%). There was no difference observed between plastic surgical patients and medical patients in acceptance of cell therapy for burns, Parkinson's disease, or diabetes. There is good potential acceptance for the use of both autologous and allogeneic cells for the treatment of acute burns and burns' scarring as well as in diabetes and Parkinson's disease. Disease state do...Continue Reading

References

Aug 29, 2000·Transfusion·M L FinucaneC K Mertz
May 19, 2001·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·K C LoweV James
May 30, 2002·Journal of Anatomy·R L Gardner
Jan 22, 2003·Xenotransplantation·Marie Omnell PerssonGöran Hermerén
Jul 5, 2005·Burns : Journal of the International Society for Burn Injuries·Matthias RabManfred Frey
Sep 6, 2005·Bulletin of Experimental Biology and Medicine·M F RasulovI V Potapov
May 9, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Alex ClarkePeter E M Butler
Aug 29, 2006·Plastic and Reconstructive Surgery·Timothy A MoseleyMarc H Hedrick
Mar 3, 2007·Burns : Journal of the International Society for Burn Injuries·A BurdL Huang
Apr 25, 2007·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Piers FlemingKenneth C Lowe
May 10, 2008·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Anna Chiara PiscagliaAntonio Gasbarrini
Sep 2, 2008·Journal of Medical Ethics·L TrommelmansK Dierickx
Oct 7, 2008·Tissue Engineering. Part B, Reviews·Rob B M de VriesBert Gordijn
Jun 13, 2009·Stem Cell Reviews and Reports·Edna EinsiedelLaura K Bennett
Jan 20, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Eric BeyJean-Jacques Lataillade
Jun 19, 2010·Journal of Cardiovascular Translational Research·Jennifer Blair McCormick, Holly A Huso
Aug 6, 2010·Nature·Daniel Sarewitz

❮ Previous
Next ❯

Citations

Aug 14, 2012·Cell and Tissue Research·Radhakrishnan VishnubalajiThiyagarajan Ramesh
May 6, 2014·Burns : Journal of the International Society for Burn Injuries·L N BurnettV Gabriel
Jan 10, 2016·Medicina intensiva·J A Lorente, R Amaya-Villar
Nov 28, 2015·Burns : Journal of the International Society for Burn Injuries·D WhelanA J P Clover
Aug 4, 2015·BioMed Research International·Fadi GhiehAbdo Jurjus
Sep 23, 2014·Burns : Journal of the International Society for Burn Injuries·Anthony J P CloverNoel M Caplice
Feb 2, 2017·Stem Cells and Development·Joseph AkedArne Lindgren
Dec 28, 2017·Plastic and Reconstructive Surgery·Anthony J P Clover, Christina E Buckley
Jan 10, 2013·Journal of Wound Care·C J Lewis
Dec 1, 2019·Journal of Economic Entomology·Mohammad Shaef UllahTetsuo Gotoh
Nov 27, 2014·Plastic and Reconstructive Surgery. Global Open·Jiad N McheikJean-Claude Lecron
Dec 10, 2020·Nature Communications·Olalekan Lee AiyegbusiMelanie J Calvert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.