Analysis of autoantibody profiles in two asbestiform fiber exposure cohorts

Journal of Toxicology and Environmental Health. Part a
Jean C PfauMarvin J Fritzler

Abstract

An increased risk for Systemic Autoimmune Diseases (SAID) was reported in the population of Libby, Montana, where extensive exposure to asbestiform amphiboles occurred through mining and use of asbestiform fiber-laden vermiculite. High frequencies of antinuclear autoantibodies (ANA) were detected in individuals and mice exposed to Libby Asbestiform Amphiboles (LAA). Among the 6603 individuals who have undergone health screening at the Center for Asbestos Related Diseases (CARD, Libby MT), the frequencies of rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, and systemic sclerosis are significantly higher than expected prevalence in the United States. While these data support the hypothesis that LAA can trigger autoimmune responses, evidence suggests that chrysotile asbestos does not. Serological testing was therefore performed in subjects exposed to LAA or predominantly chrysotile (New York steamfitters) using multiplexed array technologies. Analyses were performed in order to determine a) autoantibody profiles in each cohort, and b) whether the two populations could be distinguished through predictive modeling. Analysis using perMANOVA testing confirmed a significant difference between autoantibody profiles sugge...Continue Reading

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Citations

Dec 10, 2019·Inhalation Toxicology·Jean C PfauBrad Black
Jul 30, 2019·Frontiers in Immunology·Christine G ParksJonathan N Hofmann
Oct 7, 2020·Rheumatology·Alain LescoatCatherine Cavalin
Jan 5, 2021·Frontiers in Immunology·K Michael Pollard
Mar 9, 2021·Journal of Toxicology and Environmental Health. Part a·Renee N CareyAlison Reid
Aug 28, 2021·International Journal of Environmental Research and Public Health·Francesca IngegnoliRoberto Caporali

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Methods Mentioned

BETA
ELISA

Software Mentioned

perMANOVA
R
Core Team
pROC R
randomForest R

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