Analysis of Bacterial Biofilms on a Cochlear Implant Following Methicillin-Resistant Staphylococcus Aureus Infection

Journal of Audiology & Otology
Gi Jung ImHak Hyun Jung

Abstract

To demonstrate biofilm formations on a cochlear implant magnet of a pediatric patient suffering from a methicillin-resistant Staphylococcus aureus (MRSA) infection. The appearance of biofilm colonies was analyzed on different magnet sections. The appearance of MRSA biofilms on the surface of an explanted cochlear implant was analyzed by scanning electron microscopy (SEM), focusing on the pattern of extracellular polymeric substances (EPS) within the biofilms. SEM revealed unique biofilms with a three-dimensional EPS complex and tower-like formations. Biofilm configurations changed from the margin to the center of the magnet. Biofilms were solitary and scattered at the margin; large and plate-like in the center; and stacked in layers, forming towers and water channels, in the middle region. After a MRSA infection, biofilm formations were observed on the surface of a magnet. Bacterial biofilms provide optimal conditions for bacterial growth and antibiotic resistance and can cause intractable infections that lead to device failure.

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Citations

Mar 30, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Kerrie McAllisterMichel Neeff
Oct 9, 2019·Antibiotics·Maciej JaśkiewiczWojciech Kamysz
Jul 14, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Eric J NisenbaumDavid R Friedmann
Oct 24, 2020·The Pediatric Infectious Disease Journal·David A FoleyDaniel K Yeoh
May 25, 2021·Trends in Hearing·Nicholas L DeepSusan B Waltzman
Jan 20, 2021·ACS Biomaterials Science & Engineering·Hao WangDacheng Ren

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Methods Mentioned

BETA
cochlear implant
scanning electron microscopy
electron microscopy

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