PMID: 2487158Nov 1, 1989Paper

Analysis of BCR-ABL mRNA in chronic myelogenous leukemia patients and identification of a new BCR-related sequence in human DNA

Genes, Chromosomes & Cancer
C MarcelleE Canaani

Abstract

The Philadelphia chromosome is present in more than 95% of chronic myelogenous leukemia patients and in up to 25% of patients with acute lymphocytic leukemia. The major consequence of the aberration is the fusion of the ABL and BCR genes. The position of the breakpoint on chromosome 22 determines which species of the potential three fused mRNAs and proteins will be synthesized. We have used the polymerase chain reaction (PCR) to detect these mRNAs in 53 patients and cell lines and found that around 20% contain simultaneously two BCR-ABL mRNAs, presumably due to a process of alternative splicing. The results also indicate that most patients in lymphocytic blast crisis of CML contain the mRNA in which bcr exon 2 is linked to ABL exon II. Finally, we identified, cloned, and characterized a BCR-related sequence that originated from mRNA.

References

Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A L HoobermanC A Westbrook
Mar 1, 1989·Molecular and Cellular Biology·T G Lugo, O N Witte
Jul 1, 1989·Molecular and Cellular Biology·I K HariharanJ M Adams
Aug 25, 1988·Nucleic Acids Research·N Heisterkamp, J Groffen
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J McLaughlinO N Witte
Jun 1, 1980·European Journal of Biochemistry·C Auffray, F Rougeon

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Citations

Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·E FeinsteinE Canaani
Mar 28, 2007·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Peter DuesbergRuediger Hehlmann

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