PMID: 9449132Feb 4, 1998Paper

Analysis of biofluids and chemical mixtures in non-deuterated solvents with 1H diffusion-weighted PFG phase-sensitive double-quantum NMR spectroscopy

NMR in Biomedicine
C Dalvit, J M Böhlen

Abstract

Two different types of one- and two-dimensional diffusion-weighted H phase-sensitive pulsed field gradient double-quantum experiments (DWDQ) are presented and their application to a biological plasma sample is shown. The remarkable solvent suppression achieved with these pulse sequences and the high sensitivity of these experiments allows the determination of the diffusion coefficients of molecules at low concentration dissolved in non-deuterated solvents. Biofluids and complex chemical mixtures from combinatorial chemistry and from natural sources can be analysed with these experiments, and the different molecular species of the mixtures can be identified and assigned, based on their different diffusion coefficients.

References

Mar 1, 1995·Analytical Chemistry·J K NicholsonJ C Lindon
Apr 1, 1996·Journal of Magnetic Resonance. Series B·E K Gozansky, D G Gorenstein
Apr 1, 1996·Journal of Magnetic Resonance. Series B·C Dalvit, J M Böhlen
May 1, 1997·Journal of Magnetic Resonance·C Dalvit, J M Böhlen
Oct 18, 1996·The Journal of Organic Chemistry·Mengfen Lin, Michael J. Shapiro

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Citations

May 3, 2005·Journal of Magnetic Resonance·Konstantin I Momot, Philip W Kuchel
Oct 23, 2008·Advanced Drug Delivery Reviews·Paola Occhipinti, Peter C Griffiths
Jul 28, 2016·Magnetic Resonance in Chemistry : MRC·G N Manjunatha ReddyStefano Caldarelli
Nov 20, 2014·Chemical Communications : Chem Comm·Adrien Le GuennecJean-Nicolas Dumez
Oct 12, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Corentin Jacquemmoz, Jean-Nicolas Dumez
Sep 1, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W A BubbP W Kuchel
Jul 17, 1999·Analytical Chemistry·C K LariveS Bogdanowich-Knipp

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