PMID: 2100639Jan 1, 1990Paper

Analysis of biogenic amines and their metabolites in biological tissues and fluids by gas chromatography-negative ion chemical ionization mass spectrometry (GC-NICIMS)

Journal of Pharmaceutical and Biomedical Analysis
D G WatsonC N McGhee

Abstract

GC-NICIMS has been employed in the analysis of biogenic amines and their metabolites in human urine and human, bovine and porcine aqueous and vitreous humour. Several new chemical derivatization procedures have been developed in order to analyse these compounds. Concentrations of octopamines and synephrines were determined in urine from treated and untreated hypertensive subjects and normotensive individuals; there were no significant differences in concentrations of these metabolites between these groups. Human urine contained several dihydroxy-phenylethylamines which have not been reported as natural metabolites before and also 5- and 6-hydroxydopamine in relatively large amounts. Aqueous and vitreous humour contained very low quantities of noradrenaline, tyramine and dopamine but measurements were inconsistent because sometimes the levels were below the limits of detection. Metabolites of a number of biogenic amines were readily detected in aqueous and vitreous humour.

References

Apr 1, 1979·Acta Psychiatrica Scandinavica·H Dyggve, T Kodahl
Dec 1, 1985·American Journal of Optometry and Physiological Optics·D M Cockburn
Feb 1, 1988·British Journal of Pharmacology·C M BrownV G Wilson
Mar 1, 1987·The Journal of Pharmacy and Pharmacology·C M WilliamsJ M Midgley
Sep 1, 1987·The Journal of Pharmacy and Pharmacology·R JordanC M Williams
Jul 29, 1988·Journal of Chromatography·B Kågedal, D S Goldstein
May 1, 1988·Archives of Ophthalmology·D WatsonT M Healey
Jun 1, 1985·Journal of Neurochemistry·K E IbrahimJ M Midgley
Jan 1, 1983·Journal of Cardiovascular Pharmacology·M SchmidtJ Schwartz
Jan 1, 1983·Ophthalmic Research·G C Chiou, F Y Chiou
May 1, 1980·Journal of Neurochemistry·J M MidgleyC M Williams

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Citations

Nov 1, 1993·Journal of Pharmaceutical and Biomedical Analysis·D G WatsonK Kaiser
Oct 1, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Niwa
Dec 14, 2001·Journal of Neuroscience Methods·Jonas BergquistJerzy Silberring
Sep 21, 2011·Biomedical Chromatography : BMC·Mario ThevisWilhelm Schänzer
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad Zahid Khan, Waqas Nawaz
Aug 12, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kyung-Baeg RohDeokhoon Park
Nov 16, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Luciana Grazziotin RossatoFernando Remião

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