Analysis of bipolar disorder using affected relatives

Genetic Epidemiology
S DavisD E Weeks

Abstract

We have analyzed the GAW10 data from several studies of bipolar affective disorder (BPAD) using the software packages SimIBD and SIMWALK2. SimIBD implements a simulation-based affected-pedigree-member (APM) statistic, called SimAPM, as well as an APM-like statistic, also called SimIBD, that measures identical-by-descent (IBD) sharing. SIMWALK2 uses Markov chain Monte Carlo techniques to compute several IBD-based statistics on the degree of marker-allele clustering among all affected relatives. We have found no strong evidence of linkage to either chromosome 5 or 18. However, we did find that several markers showed p-values less than 0.01 and may deserve further study.

References

Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J Ott
Jan 1, 1994·Genetic Epidemiology·M SchroederD E Weeks
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·W H BerrettiniE S Gershon
Dec 5, 1996·Nature·C O'Brien

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Citations

Dec 20, 2000·American Journal of Medical Genetics·M Baron

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