AnaLysIs of Both sex and device specific factoRs on outcomes in pAtients with non-ischemic cardiomyopathy (BIO-LIBRA): Design and clinical protocol.

Heart Rhythm O2
Valentina KutyifaJeanne E Poole

Abstract

Outcomes of patients with nonischemic cardiomyopathy and low ejection fraction implanted with an implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy with a defibrillator (CRT-D), especially in contemporary, real-life cohorts, are not fully understood. We aimed to better characterize outcomes of death and ventricular tachyarrhythmias in patients with nonischemic cardiomyopathy, implanted with an ICD or CRT-D, and specifically assess differences by sex. The AnaLysIs of Both Sex and Device Specific FactoRs on Outcomes in PAtients with Non-Ischemic Cardiomyopathy (BIO-LIBRA) study was designed to prospectively assess outcomes of device-treated ventricular tachyarrhythmias and all-cause mortality events in nonischemic cardiomyopathy patients, indicated for an ICD or CRT-D implantation for the primary prevention of sudden cardiac death (SCD), with a specific focus on sex differences. We will enroll a total of 1000 subjects across 50 U.S. sites and follow patients for up to 3 years. The primary objective of BIO-LIBRA is to evaluate the combined risk of all-cause mortality and treated ventricular tachycardia (VT) or ventricular fibrillation (VF) events by subject sex and by implanted device type. We will a...Continue Reading

References

Mar 1, 1982·Circulation·L E Hinkle, H T Thaler
Mar 22, 2002·The New England Journal of Medicine·Arthur J MossUNKNOWN Multicenter Automatic Defibrillator Implantation Trial II Investigators
Jan 22, 2005·The New England Journal of Medicine·Gust H BardyUNKNOWN Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators
Sep 3, 2009·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-CRT Trial Investigators
Apr 13, 2011·The American Journal of Cardiology·Mori J KrantzUNKNOWN Get With the Guidelines Steering Committee and Hospitals
Mar 2, 2013·Journal of the American College of Cardiology·Laurence M EpsteinMelanie Maytin
Mar 21, 2015·Journal of Women's Health·Naomi D HerzDaniel A Caños
Jul 1, 2015·Journal of the American Heart Association·Yitschak BitonUNKNOWN MADIT‐CRT Executive Committee
Jul 5, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ramin ShadmanWayne C Levy
Mar 5, 2016·Journal of the American College of Cardiology·Gregory A RothNancy E Morden
Aug 30, 2016·The New England Journal of Medicine·Lars KøberUNKNOWN DANISH Investigators
Jul 2, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Sérgio BarraSharad Agarwal
Oct 11, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Sérgio BarraSharad Agarwal
Sep 30, 2018·Heart Rhythm : the Official Journal of the Heart Rhythm Society
May 16, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Martin K StilesUNKNOWN ESC Scientific Document Group

❮ Previous
Next ❯

Software Mentioned

MorphMatch
MADIT
LIBRA
DANISH
Home Monitoring
BIO
CRT

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Progress in Cardiovascular Diseases
Ilan Goldenberg, Arthur J Moss
Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Jenie GeorgeIlan Goldenberg
© 2021 Meta ULC. All rights reserved