Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource

Breast Cancer Research : BCR
Graham J MannKathleen Cuningham Consortium for Research in Familial Breast Cancer

Abstract

The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) is a multidisciplinary, collaborative framework for the investigation of familial breast cancer. Based in Australia, the primary aim of kConFab is to facilitate high-quality research by amassing a large and comprehensive resource of epidemiological and clinical data with biospecimens from individuals at high risk of breast and/or ovarian cancer, and from their close relatives. Epidemiological, family history and lifestyle data, as well as biospecimens, are collected from multiple-case breast cancer families ascertained through family cancer clinics in Australia and New Zealand. We used the Tyrer-Cuzick algorithms to assess the prospective risk of breast cancer in women in the kConFab cohort who were unaffected with breast cancer at the time of enrolment in the study. Of kConFab's first 822 families, 518 families had multiple cases of female breast cancer alone, 239 had cases of female breast and ovarian cancer, 37 had cases of female and male breast cancer, and 14 had both ovarian cancer as well as male and female breast cancer. Data are currently held for 11,422 people and germline DNAs for 7,389. Among the 812 families with at leas...Continue Reading

References

May 13, 1998·Cancer Causes & Control : CCC·M R McCredieJ L Hopper
May 20, 2000·Nursing Management·P PiersonJ Haas
Aug 3, 2000·International Journal of Epidemiology·J Gallacher
Jun 1, 2001·Human Mutation·W Xiao, P J Oefner
Oct 13, 2001·Breast Cancer Research : BCR·A MarshUNKNOWN Kathleen Cuningham Foundation for Research into Familial Breast Cancer
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Deborah ThompsonUNKNOWN KConFab Consortium
Feb 7, 2002·Journal of the National Cancer Institute·Georgia Chenevix-TrenchKum Kum Khanna
Apr 23, 2002·Nature Genetics·Hanne Meijers-HeijboerUNKNOWN CHEK2-Breast Cancer Consortium
Jun 20, 2002·Journal of the National Cancer Institute·Haixin LeiIgor Vorechovsky
Apr 17, 2003·American Journal of Epidemiology·Cynthia A ThomsonJames R Marshall
Jul 16, 2003·Clinical Genetics·C I ScottUNKNOWN Kathleen Cuningham Foundation Consortium for Familial Breast Cancer (kConFab)
Nov 1, 2003·Journal of Women's Health·B MeiserUNKNOWN National Consortium for Research into Familial Breast Cancer Psychological Group
Apr 2, 2004·Statistics in Medicine·Jonathan TyrerJack Cuzick
Jun 26, 2004·Breast Cancer Research : BCR·Ian G CampbellUNKNOWN Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer
Sep 24, 2004·Psycho-oncology·Phyllis ButowUNKNOWN Kathleen Cuningham Consortium for Research into Familial Breast Cancer Psychosocial Group
Dec 23, 2004·Journal of Genetic Counseling·Jacqueline LimUNKNOWN kConFab Psychosocial Group
Apr 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amanda B SpurdleUNKNOWN kConFab Investigators

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Citations

Jun 27, 2007·Breast Cancer Research and Treatment·Sharon E JohnattyUNKNOWN Kathleen Cuningham Consortium for Research in Familial Breast Cancer
May 16, 2008·Breast Cancer Research and Treatment·Sharon E JohnattyUNKNOWN Kathleen Cuningham Consortium for Research in Familial Breast Cancer
Feb 4, 2009·Breast Cancer Research and Treatment·Jeremy M ArnoldGeorgia Chenevix-Trench
Jan 22, 2010·Breast Cancer Research and Treatment·A Sauty de ChalonM C Southey
Dec 18, 2010·Breast Cancer Research and Treatment·Jonathan BeesleyGeorgia Chenevix-Trench
May 3, 2011·Breast Cancer Research and Treatment·Julie JohnsonGeorgia Chenevix-Trench
May 15, 2012·Breast Cancer Research and Treatment·Ella R ThompsonIan G Campbell
Sep 15, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Claire E WakefieldKathy Tucker
Mar 13, 2008·Journal of the National Cancer Institute·Bernd FrankBarbara Burwinkel
Oct 30, 2008·Journal of the National Cancer Institute·Felicity LoseUNKNOWN Australian Ovarian Cancer Study Management Group
Mar 24, 2010·Journal of the National Cancer Institute·Elizabeth M AzzatoPaul D P Pharoah
Jan 1, 2007·Hereditary Cancer in Clinical Practice·Joanne M McKinleyKelly-Anne Phillips
Jun 10, 2006·Breast Cancer Research : BCR·Felicity LoseUNKNOWN Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer
Aug 19, 2007·Breast Cancer Research : BCR·Felicity LoseAmanda B Spurdle
Dec 25, 2010·Breast Cancer Research : BCR·Melissa C SoutheyUNKNOWN kConFab for the Beast Cancer Family Registry
Jul 27, 2011·Breast Cancer Research : BCR·David E GoldgarGeorgia Chenevix-Trench
Mar 2, 2013·Breast Cancer Research : BCR·Zhi L TeoMelissa C Southey
Aug 27, 2013·Breast Cancer Research : BCR·Siddhartha DebStephen B Fox
Mar 24, 2011·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·David L DuffyAmanda B Spurdle
Sep 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaoqiang GuoKaiyuan Deng
Jan 5, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Kirsty J FlowerJames M Flanagan
Feb 13, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P Butow, K A Phillips
Apr 21, 2016·Human Reproduction·Kelly-Anne PhillipsUNKNOWN Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab)
Jun 21, 2016·Nature Medicine·Emma NolanGeoffrey J Lindeman
Oct 2, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian M CollinsKelly-Anne Phillips
Aug 7, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kelly-Anne PhillipsJohn L Hopper
Nov 11, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K M FieldK A Phillips
Apr 21, 2018·Psycho-oncology·Phyllis ButowUNKNOWN kConFab psychosocial investigators

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Methods Mentioned

BETA
genotyping
PCR
prophylactic surgery

Software Mentioned

Progeny Anywhere
kConFab
STATA

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