PMID: 22362033Mar 1, 2012Paper

Analysis of canine transmissible veneral tumor genotypes using the D-loop region of mitochondrial DNA

Genes & Genetic Systems
Linda G Bautista-GómezJuan Carlos Vázquez-Chagoyán

Abstract

Canine transmissible venereal tumor (CTVT) is the only neoplasm that can be spread among dogs through cell transplantation. Therefore, this tumor does not originate from host cell transformation. Although CTVT has a monophyletic origin, several studies have shown the presence of genetic diversity which was probably acquired after the development of its original clone. To investigate the genetic diversity of CTVT in Mexico and its relation with CTVTs disseminated worldwide, we sequenced a fragment of mitochondrial DNA in 50 tumor samples and matched blood samples from dog hosts from Mexico. We found ten new haplotypes in tumor samples, which were all distinct from their matched host. The TVT1 haplotype was the most frequent in our samples, suggesting that it could be the origin of the others. We found that haplotypes in Mexico and other countries are distributed in two well-defined clusters. Our data also suggest a close relationship among American haplotypes (Mexico, USA, Chile and Brazil). Interestingly, these American haplotypes were also closely related to Asian haplotypes. Taking into account the estimated timing of the origin of CTVT, we propose that CTVT might have originated in Asia; consequently, haplotypes currently pr...Continue Reading

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Citations

Dec 22, 2015·Trends in Genetics : TIG·Elaine A OstranderGary K Ostrander
May 10, 2016·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Linda Bautista-Gómez, Simón Martínez-Castañeda

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