Analysis of Canis mitochondrial DNA demonstrates high concordance between the control region and ATPase genes.

BMC Evolutionary Biology
Linda Y RutledgeBradley White

Abstract

Phylogenetic studies of wild Canis species have relied heavily on the mitochondrial DNA control region (mtDNA CR) to infer species relationships and evolutionary lineages. Previous analyses of the CR provided evidence for a North American evolved eastern wolf (C. lycaon), that is more closely related to red wolves (C. rufus) and coyotes (C. latrans) than grey wolves (C. lupus). Eastern wolf origins, however, continue to be questioned. Therefore, we analyzed mtDNA from 89 wolves and coyotes across North America and Eurasia at 347 base pairs (bp) of the CR and 1067 bp that included the ATPase6 and ATPase8 genes. Phylogenies and divergence estimates were used to clarify the evolutionary history of eastern wolves, and regional comparisons of nonsynonomous to synonomous substitutions (dN/dS) at the ATPase6 and ATPase8 genes were used to elucidate the potential role of selection in shaping mtDNA geographic distribution. We found high concordance across analyses between the mtDNA regions studied. Both had a high percentage of variable sites (CR = 14.6%; ATP = 9.7%) and both phylogenies clustered eastern wolf haplotypes monophyletically within a North American evolved lineage apart from coyotes. Divergence estimates suggest the putativ...Continue Reading

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Citations

Jun 7, 2013·BMC Evolutionary Biology·Verena E KutscheraFrank Hailer
Apr 4, 2014·Genome Biology and Evolution·José Melo-FerreiraPaulo C Alves
Feb 5, 2016·Biology Letters·L Y RutledgeB N White
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Aug 2, 2017·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Yin-Xia LiShao-Xian Cao
Mar 13, 2012·Ecology and Evolution·Linda Y RutledgeBrent R Patterson
Jul 15, 2021·Ecology and Evolution·Paul J Wilson, Linda Y Rutledge

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Datasets Mentioned

BETA
DQ480510
DQ480503
DQ480511

Software Mentioned

BEAST
ModelGenerator
ClustalW
FigTree
DnaSP
TRACER
Geneious
GENBANK

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