Analysis of cannabis in oral fluid specimens by GC-MS with automatic SPE

Science & Justice : Journal of the Forensic Science Society
Hyeyoung ChoiHeesun Chung

Abstract

Methamphetamine (MA) is the most commonly abused drug in Korea, followed by cannabis. Traditionally, MA analysis is carried out on both urine and hair samples and cannabis analysis in urine samples only. Despite the fact that oral fluid has become increasingly popular as an alternative specimen in the field of driving under the influence of drugs (DUID) and work place drug testing, its application has not been expanded to drug analysis in Korea. Oral fluid is easy to collect and handle and can provide an indication of recent drug abuse. In this study, we present an analytical method using GC-MS to determine tetrahydrocannabinol (THC) and its main metabolite 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in oral fluid. The validated method was applied to oral fluid samples collected from drug abuse suspects and the results were compared with those in urine. The stability of THC and THC-COOH in oral fluid stored in different containers was also investigated. Oral fluid specimens from 12 drug abuse suspects, submitted by the police, were collected by direct expectoration. The samples were screened with microplate ELISA. For confirmation they were extracted using automated SPE with mixed-mode cation exchange cartri...Continue Reading

Citations

Aug 12, 2014·Journal of Analytical Toxicology·Shiau Hui DiongZahurin Mohamed
Sep 9, 2011·Bioanalysis·Victoria SamanidouKonstantinos Rentifis
Dec 12, 2012·Forensic Science International : Synergy·Anna MolnarShanlin Fu
Aug 29, 2013·Drug Testing and Analysis·Dayong Lee, Marilyn A Huestis
May 3, 2011·Analytical Chemistry·T A BrettellJ R Almirall
Sep 13, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·T RosadoE Gallardo
Apr 29, 2020·Biomedical Optics Express·Damber ThapaNima Tabatabaei
Aug 19, 2021·Journal of Forensic Sciences·Roberta Petry GorzizaRenata Pereira Limberger

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