PMID: 9186683Apr 5, 1997Paper

Analysis of CD40-CD40 ligand interactions in the regulation of human B cell function

Annals of the New York Academy of Sciences
P E LipskyY Nishioka

Abstract

CD40-CD40 ligand interactions play an essential role in T cell/B cell collaboration. The data presented in this review have served to widen the scope of CD40-CD40 ligand interactions to include initial activation, proliferation, differentiation, and isotype switching of B cells, as well as subsequent downregulation of B cell function. Moreover, CD40 ligand expression by activated B cells is likely to play an essential role in facilitating ongoing responses of stimulated B cells maturing in germinal centers. Finally, CD40 expression by activated T cells may also play an important role in regulating the function of helper T cells within germinal centers. In summary, emerging data have expanded the role of CD40-CD40 ligand interaction during T cell/B cell collaboration and have emphasized its potential to regulate many of the functions of both partners in this essential interaction involved in antibody production.

References

Dec 1, 1992·European Journal of Immunology·D GrafR A Kroczek
Dec 1, 1992·The Journal of Experimental Medicine·M K SpriggsW C Fanslow
May 1, 1992·Journal of Clinical Immunology·L V IndzhiiaE A Clark
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P S Freudenthal, R M Steinman
Jun 1, 1989·The Journal of Experimental Medicine·F SchrieverL M Nadler
Nov 1, 1993·Immunology Today·R E CallardM K Spriggs
Nov 1, 1993·Journal of Clinical Immunology·M K SpriggsJ Belmont
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R FuleihanR S Geha
Sep 1, 1993·European Journal of Immunology·R J ArmitageM R Alderson
Aug 1, 1994·Immunity·J XuR A Flavell
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·A VillaE Mantuano
Nov 1, 1994·The Journal of Experimental Medicine·B R RenshawC R Maliszewski
Feb 11, 1993·Nature·J P DiSantoG de Saint Basile
Jan 1, 1996·Advances in Immunology·C Van Kooten, J Banchereau
Jan 1, 1996·Advances in Immunology·J Stavnezer

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Citations

May 16, 2008·Journal of Clinical Immunology·Fu-Yuan HuangYann-Jinn Lee
Nov 18, 2003·The Journal of Clinical Investigation·Amrie C GrammerPeter E Lipsky
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·U SchönbeckP Libby
Jan 15, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Sonia NéronJean-François Leblanc
Nov 1, 2006·Expert Review of Clinical Immunology·Chang H Kim
Jun 16, 2009·Seminars in Immunology·Daphne Y Ma, Edward A Clark
Jun 22, 2016·Scientific Reports·Delphine SauceMartin Larsen
Jun 12, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·B M ReipertH P Schwarz
Aug 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew GetahunJohn C Cambier
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S DenépouxS Lebecque
Feb 25, 2021·Therapeutic Advances in Vaccines and Immunotherapy·Katherine M EichingerNikolai Petrovsky

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