PMID: 9543672Apr 17, 1998Paper

Analysis of CD44 expression in serous and mucinous borderline tumours of the ovary: comparison with cystadenomas and overt carcinomas

Histopathology
E DaraïJ Y Scoazec

Abstract

To determine the diagnostic and prognostic value of the immunohistochemical analysis of CD44 variants in benign borderline and malignant tumours of the ovary. The reactivity of tumour cells with three monoclonal antibodies, respectively, directed to all CD44 variants, CD44-v3 isoform and CD44-v6 isoform, was assessed by using an indirect immunoperoxidase technique applied to formalin-fixed, paraffin-embedded samples of 36 cases of borderline, as compared to 20 cases of benign tumours and 20 cases of carcinomas. CD44 variants were detected in 97% of borderline tumours, as compared to 60% of benign tumours and 100% of carcinomas. CD44-v3 was detected in 25% of borderline tumours, as compared to 0% of benign tumours (P = 0.003) and 55% of carcinomas (P = 0.065). The expression of CD44-v6 was detected in 28% of borderline tumours, as compared to 20% of benign tumours and 30% of carcinomas. In borderline tumours, as in carcinomas, CD44-v6, but not CD44-v3, expression was correlated with an increased proliferative index and with a higher incidence of p53 expression. Borderline tumours of the ovary present frequent quantitative and qualitative alterations in the pattern of expression of CD44 proteins. However, these alterations are un...Continue Reading

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Citations

May 16, 1998·International Journal of Cancer. Journal International Du Cancer·M Orre, P A Rogers
Oct 6, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E Daraï, J Y Scoazec
Apr 23, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Christophe PonceletEmile Daraï
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C. W. BurgerP. Kenemans
Nov 17, 2015·Biomolecules·Joelle D Sacks, Maria V Barbolina
Aug 3, 2006·The Journal of Obstetrics and Gynaecology Research·Soon Cheol HongKyu Wan Lee
Nov 7, 2000·Gynecologic Oncology·I Sancho-TorresL Rodríguez-Rodríguez
Jun 15, 2016·Archives of Gynecology and Obstetrics·Luyang ZhaoYuanguang Meng
Nov 10, 2009·Journal of Pediatric and Adolescent Gynecology·Minoru IwasakiTatsuyoshi Saiga

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